VS-105 | CAS#1469985-12-3 | cardioprotective

MedKoo Cat#: 585378 | Name: VS-105

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VS-105 is a vitamin D receptor modulator and cardioprotective agent.

Chemical Structure

VS-105

CAS#1469985-12-3

Theoretical Analysis

MedKoo Cat#: 585378

Name: VS-105

CAS#: 1469985-12-3

Chemical Formula: C27H44O4

Exact Mass: 432.3240

Molecular Weight: 432.65

Elemental Analysis: C, 74.96; H, 10.25; O, 14.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

VS-105; VS105; VS 105

IUPAC/Chemical Name

5-(2-(1-(1-(3-hydroxy-2,3-dimethylbutoxy)ethyl)-7alpha-methyldihydro-1H-inden-4(2H,5H,6H,7H,7alphaH)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol

InChi Key

XTETWRPMAYCPJP-QWYISMQYSA-N

InChi Code

InChI=1S/C27H44O4/c1-16-7-9-21(10-8-20-13-24(28)18(3)25(29)14-20)23-12-11-22(26(16)23)19(4)31-15-17(2)27(5,6)30/h8,10,16-17,19,22-26,28-30H,3,7,9,11-15H2,1-2,4-6H3/b20-8?,21-10+/t16-,17?,19?,22?,23?,24?,25?,26?/m0/s1

SMILES Code

OC1C(C(O)C/C(C1)=C/C=C2C3CCC(C(OCC(C)C(C)(O)C)C)C3[C@@H](C)CC/2)=C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 432.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sawada K, Wu-Wong JR, Chen YW, Wessale JL, Kanai G, Kakuta T, Fukagawa M. Vitamin D receptor agonist VS-105 directly modulates parathyroid hormone expression in human parathyroid cells and in 5/6 nephrectomized rats. J Steroid Biochem Mol Biol. 2017 Mar;167:48-54. doi: 10.1016/j.jsbmb.2016.10.008. Epub 2016 Oct 29. PubMed PMID: 27989797. 2: Fujii H, Yonekura Y, Nakai K, Kono K, Goto S, Nishi S. Comparison of the effects of novel vitamin D receptor analog VS-105 and paricalcitol on chronic kidney disease-mineral bone disorder in an experimental model of chronic kidney disease. J Steroid Biochem Mol Biol. 2017 Mar;167:55-60. doi: 10.1016/j.jsbmb.2016.11.002. Epub 2016 Nov 3. PubMed PMID: 27818277. 3: Wu-Wong JR, Chen YW, Wessale JL. Vitamin D receptor agonist VS-105 improves cardiac function in the presence of enalapril in 5/6 nephrectomized rats. Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F309-19. doi: 10.1152/ajprenal.00129.2014. Epub 2014 Dec 10. PubMed PMID: 25503724; PubMed Central PMCID: PMC4329489. 4: Wu-Wong JR, Kawai M, Chen YW, Nakane M. VS-105: a novel vitamin D receptor modulator with cardiovascular protective effects. Br J Pharmacol. 2011 Sep;164(2b):551-60. doi: 10.1111/j.1476-5381.2011.01473.x. PubMed PMID: 21557735; PubMed Central PMCID: PMC3188908. 5: Chen B, Kawai M, Wu-Wong JR. Synthesis of VS-105: A novel and potent vitamin D receptor agonist with reduced hypercalcemic effects. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5949-52. doi: 10.1016/j.bmcl.2013.08.076. Epub 2013 Aug 24. PubMed PMID: 24035340. 6: Mizobuchi M, Ogata H, Yamazaki-Nakazawa A, Hosaka N, Kondo F, Koiwa F, Kinugasa E, Shibata T. Cardiac effect of vitamin D receptor modulators in uremic rats. J Steroid Biochem Mol Biol. 2016 Oct;163:20-7. doi: 10.1016/j.jsbmb.2016.03.028. Epub 2016 Apr 9. PubMed PMID: 27072785. 7: Song T, Lee SH. Barbed suture vs traditional suture in single-port total laparoscopic hysterectomy. 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