Synonym
BC-1215; BC 1215; BC1215
IUPAC/Chemical Name
N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine
InChi Key
IXEPQJQQSLMESJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2
SMILES Code
C1(CNCCNCC2=CC=C(C3=NC=CC=C3)C=C2)=CC=C(C4=NC=CC=C4)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
394.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jeon S, Kang J, Lee SB. BC-1215 inhibits ATP-induced IL-1β secretion via the
FBXL2-mediated ubiquitination and degradation of not only NLRP3, but also pro-
IL-1β in LPS-primed THP-1 cells. Biochem Biophys Res Commun. 2023 May
21;657:128-135. doi: 10.1016/j.bbrc.2023.03.055. Epub 2023 Mar 22. PMID:
37004285.
2: Hung KY, Liao WI, Pao HP, Wu SY, Huang KL, Chu SJ. Targeting F-Box Protein
Fbxo3 Attenuates Lung Injury Induced by Ischemia-Reperfusion in Rats. Front
Pharmacol. 2019 May 24;10:583. doi: 10.3389/fphar.2019.00583. PMID: 31178737;
PMCID: PMC6544082.
3: Gao Y, Xiao X, Luo J, Wang J, Peng Q, Zhao J, Jiang N, Zhao Y. E3 Ubiquitin
Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion
Injury. Int J Mol Sci. 2022 Nov 7;23(21):13648. doi: 10.3390/ijms232113648.
PMID: 36362432; PMCID: PMC9658360.
4: Hsieh MC, Ho YC, Lai CY, Wang HH, Yang PS, Cheng JK, Chen GD, Ng SC, Lee AS,
Tseng KW, Lin TB, Peng HY. Blocking the Spinal Fbxo3/CARM1/K+ Channel
Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief.
Neurotherapeutics. 2021 Apr;18(2):1295-1315. doi: 10.1007/s13311-020-00977-5.
Epub 2021 Jan 7. PMID: 33415686; PMCID: PMC8423947.
5: Lin TB, Hsieh MC, Lai CY, Cheng JK, Chau YP, Ruan T, Chen GD, Peng HY.
Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the
TRAF2/TNIK/GluR1 Cascade. J Neurosci. 2015 Dec 16;35(50):16545-60. doi:
10.1523/JNEUROSCI.2301-15.2015. PMID: 26674878; PMCID: PMC6605509.
