LY 231617 | CAS#93811-58-6 | Antioxidant

MedKoo Cat#: 525523 | Name: LY 231617

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 231617 is a potent antioxidant that readily crosses the blood-brain barrier. LY 231617 significantly reduces ischemia-induced or hydrogen peroxide-induced neuronal damage and inhibits lipid peroxidation (IC50 = 22 µM). LY 231617 prevents nuclear translocation of activated NF-κB in hippocampal neurons.

Chemical Structure

LY 231617

CAS#93811-58-6

Theoretical Analysis

MedKoo Cat#: 525523

Name: LY 231617

CAS#: 93811-58-6

Chemical Formula: C17H29NO

Exact Mass: 263.2249

Molecular Weight: 263.43

Elemental Analysis: C, 77.51; H, 11.10; N, 5.32; O, 6.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LY 231617; LY-231617; LY231617.

IUPAC/Chemical Name

p-Cresol, 2,6-di-tert-butyl-alpha-(ethylamino)-

InChi Key

WQNYIWJBDGLKEB-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H29NO/c1-8-18-11-12-9-13(16(2,3)4)15(19)14(10-12)17(5,6)7/h9-10,18-19H,8,11H2,1-7H3

SMILES Code

CCNCC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 263.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shani V, Bromberg Y, Sperling O, Zoref-Shani E. Involvement of Src tyrosine kinases (SFKs) and of focal adhesion kinase (FAK) in the injurious mechanism in rat primary neuronal cultures exposed to chemical ischemia. J Mol Neurosci. 2009 Jan;37(1):50-9. doi: 10.1007/s12031-008-9113-3. Epub 2008 Jun 27. PubMed PMID: 18584337. 2: Toung TJ, Bhardwaj A, Wang M, Kirsch JR, Traystman RJ. Antioxidant LY231617 enhances electrophysiologic recovery after global cerebral ischemia in dogs. Crit Care Med. 2000 Jan;28(1):196-201. PubMed PMID: 10667522. 3: Fuson KS, Mark RJ, Panetta JA, May PC. Characterization of LY231617 protection against hydrogen peroxide toxicity. J Neurochem. 1999 Mar;72(3):1154-60. PubMed PMID: 10037488. 4: Clemens JA, Stephenson DT, Yin T, Smalstig EB, Panetta JA, Little SP. Drug-induced neuroprotection from global ischemia is associated with prevention of persistent but not transient activation of nuclear factor-kappaB in rats. Stroke. 1998 Mar;29(3):677-82. PubMed PMID: 9506612. 5: O'Neill MJ, Hicks C, Ward M, Panetta JA. Neuroprotective effects of the antioxidant LY231617 and NO synthase inhibitors in global cerebral ischaemia. Brain Res. 1997 Jun 20;760(1-2):170-8. PubMed PMID: 9237532. 6: Block F, Schwarz M. Correlation between hippocampal neuronal damage and spatial learning deficit due to global ischemia. Pharmacol Biochem Behav. 1997 Apr;56(4):755-61. PubMed PMID: 9130303. 7: Inoue N, Yamamoto YL, Korematsu K, Goto S, Nagahiro S, Oyama T, Yamada K, Ushio Y. Effectiveness of retrograde perfusion of the cerebral vein for attenuating neuronal injury after transient ischemia following reperfusion in the rat brain. Neurol Med Chir (Tokyo). 1997 Mar;37(3):243-9. PubMed PMID: 9095624. 8: May PC, Clemens JA, Panetta JA, Smalstig EB, Stephenson D, Fuson KS. Induction of sulfated glycoprotein-2 (clusterin) and glial fibrillary acidic protein (GFAP) RNA expression following transient global ischemia is differentially attenuated by LY231617. Brain Res Mol Brain Res. 1996 Nov;42(1):145-8. PubMed PMID: 8915593. 9: Millar AD, Rampton DS, Chander CL, Claxson AW, Blades S, Coumbe A, Panetta J, Morris CJ, Blake DR. Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis. Gut. 1996 Sep;39(3):407-15. PubMed PMID: 8949646; PubMed Central PMCID: PMC1383348. 10: Inoue N, Yamamoto YL, Ito Y, Clemens JA, Panetta JK, Diksic M. The efficacy of retrograde infusion with LY231617 in a rat middle cerebral artery occlusion model. Can J Neurol Sci. 1996 Aug;23(3):175-83. PubMed PMID: 8862838. 11: Wright JW, Clemens JA, Panetta JA, Smalstig EB, Weatherly LA, Kramár EA, Pederson ES, Mungall BH, Harding JW. Effects of LY231617 and angiotensin IV on ischemia-induced deficits in circular water maze and passive avoidance performance in rats. Brain Res. 1996 Apr 22;717(1-2):1-11. PubMed PMID: 8738247. 12: Nagao T, Yamamoto YL, Inoue N, Ito Y. Retrograde perfusion of the cerebral vein with antioxidant LY231617 reduces brain damage in the rat focal ischemia model. Neurol Med Chir (Tokyo). 1995 Dec;35(12):861-8. PubMed PMID: 8584082. 13: Block F, Schmitt W, Schwarz M. The antioxidant LY 231617 ameliorates functional and morphological sequelae induced by global ischemia in rats. Brain Res. 1995 Oct 2;694(1-2):308-11. PubMed PMID: 8974659. 14: Brewster ME, Anderson WR, Estes KS, Bodor NS, Pop E, Panetta JA. Tissue distribution of LY231617, an antioxidant with neuroprotectant activity, in the rat. J Pharm Sci. 1995 Jul;84(7):791-3. PubMed PMID: 7562425. 15: Panetta JA, Clemens JA. Novel antioxidant therapy for cerebral ischemia-reperfusion injury. Ann N Y Acad Sci. 1994 Jun 17;723:239-45. PubMed PMID: 8030869. 16: Clemens JA, Smalstig EB, Bhagwandin B, Panetta JA. Preservation of a functionally intact neuronal network after global ischemia. Neurosci Lett. 1994 Apr 11;170(2):244-6. PubMed PMID: 8058197. 17: Clemens JA, Saunders RD, Ho PP, Phebus LA, Panetta JA. The antioxidant LY231617 reduces global ischemic neuronal injury in rats. Stroke. 1993 May;24(5):716-22; discussion 722-3. PubMed PMID: 8488528.