RDS-127 | CAS#82668-32-4 | dopamine-receptor agonist

MedKoo Cat#: 145466 | Name: RDS-127

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RDS-127 produces biphasic, dose-related changes in rat spontaneous locomotor activity similar to that reported for APO. The locomotor stimulant effects of RDS-127 were 3 times more potent and 4 times greater in duration than that induced by APO. RDS-127 is significantly more selective than APO in preferentially activating DA autoreceptors as opposed to the postsynaptic DA receptors in the nigrostriatal pathway.

Chemical Structure

RDS-127

CAS#82668-32-4

Theoretical Analysis

MedKoo Cat#: 145466

Name: RDS-127

CAS#: 82668-32-4

Chemical Formula: C17H27NO2

Exact Mass: 277.2000

Molecular Weight: 277.41

Elemental Analysis: C, 73.61; H, 9.81; N, 5.05; O, 11.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

RDS-127; RDS127; RDS 127;

IUPAC/Chemical Name

4,7-dimethoxy-N,N-dipropyl-2,3-dihydro-1H-inden-2-amine

InChi Key

FPAHQTSJKYIURQ-UHFFFAOYSA-N

InChi Code

1S/C17H27NO2/c1-5-9-18(10-6-2)13-11-14-15(12-13)17(20-4)8-7-16(14)19-3/h7-8,13H,5-6,9-12H2,1-4H3

SMILES Code

CCCN(CCC)C1CC2=C(OC)C=CC(OC)=C2C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 277.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Arnerić SP, Long JP, Williams M, Goodale DB, Mott J, Lakoski JM, Gebhart GF. RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist. J Pharmacol Exp Ther. 1983 Jan;224(1):161-70. PMID: 6401334. 2: Arnerić SP, Roetker A, Long JP. Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists. Neuropharmacology. 1982 Sep;21(9):885-90. doi: 10.1016/0028-3908(82)90080-6. PMID: 6897285. 3: Clark JT, Peroutka SJ, Ciaranello RD, Smith ER, Davidson JM. Central effects of RDS-127: sexual behavior after intracerebroventricular administration and in vitro receptor binding studies. Behav Brain Res. 1985 Dec;18(3):251-60. doi: 10.1016/0166-4328(85)90033-6. PMID: 2936365. 4: Stefanick ML, Smith ER, Clark JT, Davidson JM. Effects of a potent dopamine receptor agonist, RDS-127, on penile reflexes and seminal emission in intact and spinally transected rats. Physiol Behav. 1982 Dec;29(6):973-8. doi: 10.1016/0031-9384(82)90286-4. PMID: 7163401. 5: Clark JT, Smith ER. Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior. Physiol Behav. 1986;37(1):47-52. doi: 10.1016/0031-9384(86)90382-3. PMID: 3737722. 6: Clark JT, Stefanick ML, Smith ER, Davidson JM. Further studies on alterations in male rat copulatory behavior induced by the dopamine-receptor agonist RDS-127. Pharmacol Biochem Behav. 1983 Nov;19(5):781-6. doi: 10.1016/0091-3057(83)90080-1. PMID: 6647512. 7: Clark JT, Smith ER, Stefanick ML, Arnerić SP, Long JP, Davidson JM. Effects of a novel dopamine-receptor agonist RDS-127 (2-N,N-di-n- propylamino-4,7-dimethoxyindane), on hormone levels and sexual behavior in the male rat. Physiol Behav. 1982 Jul;29(1):1-6. doi: 10.1016/0031-9384(82)90357-2. PMID: 7122715. 8: Pinnock RD. Action of putative dopamine receptor agonists, TL-99, 3-PPP and RDS-127 on substantia nigra neurons. Brain Res. 1984 Jan 30;292(1):190-3. doi: 10.1016/0006-8993(84)90907-7. PMID: 6697209. 9: Sahin I, Ilhan M. The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig. Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:163-72. PMID: 2907277. 10: Arnerić SP, Long JP. Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions. J Pharm Pharmacol. 1984 May;36(5):318-21. doi: 10.1111/j.2042-7158.1984.tb04382.x. PMID: 6145768. 11: Rezaki YE, Ilhan M. Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae. Arch Int Pharmacodyn Ther. 1991 Mar-Apr;310:76-86. PMID: 1685313. 12: Sahin I, Tuncer M, Ilhan M. Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice. Arch Int Physiol Biochim. 1990 Mar;98(1):7-9. doi: 10.3109/13813459009115730. PMID: 1692697. 13: Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF. Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives. Arch Int Pharmacodyn Ther. 1982 Jun;257(2):263-73. PMID: 7114973. 14: Arnerić SP, Chow SA, Long JP, Fischer LJ. Dopamine analog-induced hyperglycemia in rats: involvement of the adrenal medulla and the endocrine pancreas. J Pharmacol Exp Ther. 1984 Mar;228(3):551-9. PMID: 6142939. 15: Arnerić SP, Chow SA, Long JP, Fischer LJ. Inhibition of insulin release from rat pancreatic islets by drugs that are analogues of dopamine. Diabetes. 1984 Sep;33(9):888-93. doi: 10.2337/diab.33.9.888. PMID: 6147289. 16: Kwong LL, Smith ER, Davidson JM, Peroutka SJ. Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors. Behav Neurosci. 1986 Oct;100(5):664-8. doi: 10.1037//0735-7044.100.5.664. PMID: 2877677. 17: Arnerić SP, Collins ED, Bhatnagar RK, Long JP. Is domperidone a selective peripheral dopamine-receptor antagonist in vivo? Neuropharmacology. 1982 Dec;21(12):1317-21. doi: 10.1016/0028-3908(82)90140-x. PMID: 7155311.