MedKoo Cat#: 462532 | Name: Vps34-IN-2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34.

Chemical Structure

Vps34-IN-2
Vps34-IN-2
CAS#1523404-29-6

Theoretical Analysis

MedKoo Cat#: 462532

Name: Vps34-IN-2

CAS#: 1523404-29-6

Chemical Formula: C18H25F3N4O3

Exact Mass: 402.1879

Molecular Weight: 402.42

Elemental Analysis: C, 53.72; H, 6.26; F, 14.16; N, 13.92; O, 11.93

Price and Availability

Size Price Availability Quantity
1mg USD 410.00 2 Weeks
5mg USD 1,000.00 2 Weeks
10mg USD 1,510.00 2 Weeks
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Related CAS #
No Data
Synonym
Vps34-IN-2; Vps34-IN 2; Vps34 IN-2; Vps34 IN 2
IUPAC/Chemical Name
(S)-9-(3-methyl-2-oxobutyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one
InChi Key
ITCIAOUZMPREOO-OCCSQVGLSA-N
InChi Code
InChI=1S/C18H25F3N4O3/c1-11(2)13(26)9-25-14(18(19,20)21)4-5-24-16(27)8-15(22-17(24)25)23-6-7-28-10-12(23)3/h8,11-12,14H,4-7,9-10H2,1-3H3/t12-,14+/m1/s1
SMILES Code
O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC(C(C)C)=O)[C@H](C(F)(F)F)CCN31
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 402.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pasquier B, El-Ahmad Y, Filoche-Rommé B, et al. Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. J Med Chem. 2015;58(1):376-400. doi:10.1021/jm5013352