CZ-01127 | CAS#N/A | first-in-class antibiotic

MedKoo Cat#: 565788 | Name: CZ-01127

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CZ-01127 is a unique first-in-class antibiotic, being more effective at killing pathogenic methicillin resistant staphylococcus aureus (mrsa) bacteria than two clinical gold-standard antibiotics-vancomycin and gentamicin

Chemical Structure

CZ-01127

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565788

Name: CZ-01127

CAS#: N/A

Chemical Formula: C54H97N9

Exact Mass: 871.7867

Molecular Weight: 872.43

Elemental Analysis: C, 74.34; H, 11.21; N, 14.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CZ-01127; CZ 01127; CZ01127

IUPAC/Chemical Name

N1,N1',N1''-([1,1'-Biphenyl]-3,3',5-triyltris(methylene))tris(N3-(3-((cyclohexylmethyl)amino)propyl)propane-1,3-diamine)

InChi Key

OOIFMFIENWQWJW-UHFFFAOYSA-N

InChi Code

InChI=1S/C54H97N9/c1-4-17-47(18-5-1)41-58-31-11-25-55-28-14-34-61-44-50-23-10-24-53(38-50)54-39-51(45-62-35-15-29-56-26-12-32-59-42-48-19-6-2-7-20-48)37-52(40-54)46-63-36-16-30-57-27-13-33-60-43-49-21-8-3-9-22-49/h10,23-24,37-40,47-49,55-63H,1-9,11-22,25-36,41-46H2

SMILES Code

C1(C2=CC=CC(CNCCCNCCCNCC3CCCCC3)=C2)=CC(CNCCCNCCCNCC4CCCCC4)=CC(CNCCCNCCCNCC5CCCCC5)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 872.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Williams DL, Epperson RT, Ashton NN, Taylor NB, Kawaguchi B, Olsen RE, Haussener TJ, Sebahar PR, Allyn G, Looper RE. In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection. Acta Biomater. 2019 Jul 15;93:36-49. doi: 10.1016/j.actbio.2019.01.055. Epub 2019 Jan 31. PubMed PMID: 30710710. 2: Ashton NN, Allyn G, Porter ST, Haussener TJ, Sebahar PR, Looper RE, Williams DL. In vitro testing of a first-in-class tri-alkylnorspermidine-biaryl antibiotic in an anti-biofilm silicone coating. Acta Biomater. 2019 Jul 15;93:25-35. doi: 10.1016/j.actbio.2019.02.010. Epub 2019 Feb 12. PubMed PMID: 30769135.