D-473 | CAS#1632000-05-5 | Triple reuptake inhibitor

MedKoo Cat#: 464651 | Name: D-473

Description:

WARNING: This product is for research use only, not for human or veterinary use.

D-473 is a novel orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters.

Chemical Structure

D-473

CAS#1632000-05-5

Theoretical Analysis

MedKoo Cat#: 464651

Name: D-473

CAS#: 1632000-05-5

Chemical Formula: C26H27F2NO3

Exact Mass: 439.1959

Molecular Weight: 439.50

Elemental Analysis: C, 71.05; H, 6.19; F, 8.65; N, 3.19; O, 10.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

D-473; D473; D 473;

IUPAC/Chemical Name

(2S,4R,5R)-2-(bis(4-fluorophenyl)methyl)-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol

InChi Key

BEJMRCNDXXJWEL-SDHSZQHLSA-N

InChi Code

InChI=1S/C26H27F2NO3/c1-31-22-12-2-17(3-13-22)15-29-23-16-32-25(14-24(23)30)26(18-4-8-20(27)9-5-18)19-6-10-21(28)11-7-19/h2-13,23-26,29-30H,14-16H2,1H3/t23-,24-,25+/m1/s1

SMILES Code

O[C@@H]1C[C@@H](C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)OC[C@H]1NCC4=CC=C(OC)C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 439.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Dutta AK, Santra S, Sharma H, Voshavar C, Xu L, Mabrouk O, Antonio T, Reith ME. Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters. PLoS One. 2014 Nov 26;9(11):e113420. doi: 10.1371/journal.pone.0113420. PMID: 25427177; PMCID: PMC4245125. 2: Santra S, Kortagere S, Vedachalam S, Gogoi S, Antonio T, Reith MEA, Dutta AK. Novel Potent Dopamine-Norepinephrine and Triple Reuptake Uptake Inhibitors Based on Asymmetric Pyran Template and Their Molecular Interactions with Monoamine Transporters. ACS Chem Neurosci. 2021 Apr 21;12(8):1406-1418. doi: 10.1021/acschemneuro.1c00078. Epub 2021 Apr 12. PMID: 33844493.