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MedKoo Cat#: 558737 | Name: (S)-B-973B
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

(S)-B-973B is a potent ago-PAM of α7 nAChR.

Chemical Structure

(S)-B-973B
(S)-B-973B
CAS#2244989-34-0

Theoretical Analysis

MedKoo Cat#: 558737

Name: (S)-B-973B

CAS#: 2244989-34-0

Chemical Formula: C24H26F2N6O

Exact Mass: 452.2136

Molecular Weight: 452.51

Elemental Analysis: C, 63.70; H, 5.79; F, 8.40; N, 18.57; O, 3.54

Price and Availability

Size Price Availability Quantity
10mg USD 425.00
50mg USD 1,450.00
500mg USD 3,950.00
1g USD 4,950.00
2g USD 8,950.00
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Related CAS #
No Data
Synonym
(S) B-973B; (S)-B 973B; (S)-B973B; (S)-B-973B; (-)-(S)-B-973B
IUPAC/Chemical Name
(S)-3-(3,4-Difluorophenyl)-N-(1-(6-(4-(pyridin-2-yl)piperazin-1-yl)pyrazin-2-yl)ethyl)propanamide
InChi Key
WQYZERNSONBUCW-KRWDZBQOSA-N
InChi Code
InChI=1S/C24H26F2N6O/c1-17(29-24(33)8-6-18-5-7-19(25)20(26)14-18)21-15-27-16-23(30-21)32-12-10-31(11-13-32)22-4-2-3-9-28-22/h2-5,7,9,14-17H,6,8,10-13H2,1H3,(H,29,33)/t17-/m0/s1
SMILES Code
O=C(N[C@H](C1=NC(N2CCN(C3=NC=CC=C3)CC2)=CN=C1)C)CCC4=CC=C(F)C(F)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 452.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Quadri M, Garai S, Thakur GA, Stokes C, Gulsevin A, Horenstein NA, Papke RL. Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107. Mol Pharmacol. 2019 Jan;95(1):43-61. doi: 10.1124/mol.118.113340. Epub 2018 Oct 22. PubMed PMID: 30348894; PubMed Central PMCID: PMC6277926.