Vardenafil HCl | BAY 38-9456 | CAS#224789-15-5 | CAS#224785-90-4 | PDE5 Inhibitor

MedKoo Cat#: 318973 | Name: Vardenafil HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vardenafil, also known as BAY 38-9456, is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's.

Chemical Structure

Vardenafil HCl

CAS#224789-15-5 (2HCl)

Theoretical Analysis

MedKoo Cat#: 318973

Name: Vardenafil HCl

CAS#: 224789-15-5 (2HCl)

Chemical Formula: C23H34Cl2N6O4S

Exact Mass: 0.0000

Molecular Weight: 561.52

Elemental Analysis: C, 49.20; H, 6.10; Cl, 12.63; N, 14.97; O, 11.40; S, 5.71

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Related CAS #

224789-15-5 (2HCl) 224785-90-4 (free) 330808-88-3 (HCl trihydrate)

Synonym

BAY 38-9456; BAY-38-9456; BAY38-9456; Vardenafil HCl; Levitra; Staxyn; Vivanza

IUPAC/Chemical Name

2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one dihydrochloride

InChi Key

NOIHTGOGFDFCBN-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H32N6O4S.2ClH/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28;;/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30);2*1H

SMILES Code

O=C1N=C(C2=CC(S(=O)(N3CCN(CC)CC3)=O)=CC=C2OCC)NN4C1=C(C)N=C4CCC.[H]Cl.[H]Cl

Appearance

White to off-white crystalline powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# CAS#224789-15-5 (Vardenafil dihydrochloride); CAS#224785-90-4 (Vardenafil free base). CAS#330808-88-3 (Vardenafil hydrochloride trihydrate)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 561.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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