TB47| CAS#N/A| (qcrb) inhibitor| MedKoo

MedKoo Cat#: 565506 | Name: TB47

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TB47 is a novel putative respiratory complex iii (qcrb) inhibitor, being actively against a panel of 56 m. tuberculosis clinical isolates, including 37 multi-drug-resistant and two extensively drug-resistant strains

Chemical Structure

TB47

CAS#CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565506

Name: TB47

CAS#: CAS#N/A

Chemical Formula: C29H29F3N4O3

Exact Mass: 538.2192

Molecular Weight: 538.57

Elemental Analysis: C, 64.67; H, 5.43; F, 10.58; N, 10.40; O, 8.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TB47; TB 47; TB-47

IUPAC/Chemical Name

5-Methoxy-2-methyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)pyrazolo[1,5-a]pyridine-3-carboxamide

InChi Key

HQECXZKIRDUGLC-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H29F3N4O3/c1-19-27(26-17-25(38-2)13-16-36(26)34-19)28(37)33-18-20-3-7-23(8-4-20)35-14-11-22(12-15-35)21-5-9-24(10-6-21)39-29(30,31)32/h3-10,13,16-17,22H,11-12,14-15,18H2,1-2H3,(H,33,37)

SMILES Code

O=C(C1=C2C=C(OC)C=CN2N=C1C)NCC3=CC=C(N4CCC(C5=CC=C(OC(F)(F)F)C=C5)CC4)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 538.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liu Y, Gao Y, Liu J, Tan Y, Liu Z, Chhotaray C, Jiang H, Lu Z, Chiwala G, Wang S, Makafe G, Islam MM, Hameed HMA, Cai X, Wang C, Li X, Tan S, Zhang T. The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model. Nat Commun. 2019 Jan 31;10(1):524. doi: 10.1038/s41467-019-08464-y. PubMed PMID: 30705268; PubMed Central PMCID: PMC6355801. 2: Lu X, Williams Z, Hards K, Tang J, Cheung CY, Aung HL, Wang B, Liu Z, Hu X, Lenaerts A, Woolhiser L, Hastings C, Zhang X, Wang Z, Rhee K, Ding K, Zhang T, Cook GM. Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis. ACS Infect Dis. 2019 Feb 8;5(2):239-249. doi: 10.1021/acsinfecdis.8b00225. Epub 2018 Dec 11. PubMed PMID: 30485737.