IMP-321 | CAS# 928150-91-8 | Biochemical

MedKoo Cat#: 576641 | Name: IMP-321

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IMP-321 is a soluble dimeric recombinant form of LAG-3 and first-in-class antigen presenting cell activator.

Chemical Structure

IMP-321

CAS#928150-91-8

Theoretical Analysis

MedKoo Cat#: 576641

Name: IMP-321

CAS#: 928150-91-8

Chemical Formula: C56H78N18O14S

Exact Mass: 1258.5666

Molecular Weight: 1259.41

Elemental Analysis: C, 53.41; H, 6.24; N, 20.02; O, 17.78; S, 2.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IMP-321; IMP 321; IMP321

IUPAC/Chemical Name

D-Lysinamide, N-(4-((hydrazinylthioxomethyl)amino)benzoyl)-D-tyrosyl-N6-(N-(4-((2-(1H-imidazol-5-yl)ethyl)amino)-1,4-dioxobutyl)glycyl)-D-lysyl-D-alpha-glutamyl-N6-(N-(4-((2-(1H-imidazol-5-yl)ethyl)amino)-1,4-dioxobutyl)glycyl)-

InChi Key

ONKCBKDTKZIWHZ-MRWFHJSOSA-N

InChi Code

InChI=1S/C56H78N18O14S/c57-23-3-1-6-41(70-55(88)43(27-34-7-13-39(75)14-8-34)72-52(85)35-9-11-36(12-10-35)68-56(89)73-59)53(86)71-42(15-20-50(82)83)54(87)69-40(51(58)84)5-2-4-26-74(48(80)30-64-46(78)18-16-44(76)62-24-21-37-28-60-32-66-37)49(81)31-65-47(79)19-17-45(77)63-25-22-38-29-61-33-67-38/h7-14,28-29,32-33,40-43,75H,1-6,15-27,30-31,57,59H2,(H2,58,84)(H,60,66)(H,61,67)(H,62,76)(H,63,77)(H,64,78)(H,65,79)(H,69,87)(H,70,88)(H,71,86)(H,72,85)(H,82,83)(H2,68,73,89)/t40-,41-,42-,43-/m1/s1

SMILES Code

NCCCC[C@@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)c2ccc(NC(=S)NN)cc2)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CCCCN(C(=O)CNC(=O)CCC(=O)NCCc3cnc[nH]3)C(=O)CNC(=O)CCC(=O)NCCc4cnc[nH]4)C(=O)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,259.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Dirix L, Triebel F. AIPAC: a Phase IIb study of eftilagimod alpha (IMP321 or LAG-3Ig) added to weekly paclitaxel in patients with metastatic breast cancer. Future Oncol. 2019 Jun;15(17):1963-1973. doi: 10.2217/fon-2018-0807. Epub 2019 Apr 12. PMID: 30977393. 2. Anderson AC, Joller N, Kuchroo VK. Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation. Immunity. 2016 May 17;44(5):989-1004. doi: 10.1016/j.immuni.2016.05.001. PMID: 27192565; PMCID: PMC4942846.