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MedKoo Cat#: 464485 | Name: Trifolin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trifolin is a flavonoid that has been found in C. vulgaris and has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory properties. It inhibits secretory phospholipase A2 (sPLA2) with an IC50 value of 17.6 µM. Trifolin (12.5, 25, and 50 µM) decreases protein levels of Akt and induces apoptosis in NCI H460 non-small cell lung cancer (NSCLC) cells. It scavenges DPPH radicals and superoxide anions in cell-free assays when used at a concentration of 200 µg/ml. Trifolin reduces ear and paw edema induced by phorbol 12-myristate 13-acetate and carrageenan, respectively, in mice when administered at a dose of 150 mg/kg. is a flavonoid that has been found in C. vulgaris and has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory properties. It inhibits secretory phospholipase A2 (sPLA2) with an IC50 value of 17.6 µM. Trifolin (12.5, 25, and 50 µM) decreases protein levels of Akt and induces apoptosis in NCI H460 non-small cell lung cancer (NSCLC) cells. It scavenges DPPH radicals and superoxide anions in cell-free assays when used at a concentration of 200 µg/ml. Trifolin reduces ear and paw edema induced by phorbol 12-myristate 13-acetate and carrageenan, respectively, in mice when administered at a dose of 150 mg/kg.

Chemical Structure

Trifolin
Trifolin
CAS#23627-87-4

Theoretical Analysis

MedKoo Cat#: 464485

Name: Trifolin

CAS#: 23627-87-4

Chemical Formula: C21H20O11

Exact Mass: 448.1006

Molecular Weight: 448.38

Elemental Analysis: C, 56.25; H, 4.50; O, 39.25

Price and Availability

Size Price Availability Quantity
1mg USD 450.00 2 Weeks
5mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Trifolin; Kaempferol 3-O-galactoside;
IUPAC/Chemical Name
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChi Key
JPUKWEQWGBDDQB-DTGCRPNFSA-N
InChi Code
InChI=1S/C21H20O11/c22-7-13-15(26)17(28)18(29)21(31-13)32-20-16(27)14-11(25)5-10(24)6-12(14)30-19(20)8-1-3-9(23)4-2-8/h1-6,13,15,17-18,21-26,28-29H,7H2/t13-,15+,17+,18-,21+/m1/s1
SMILES Code
O=C1C2=C(C=C(C=C2OC(C3=CC=C(O)C=C3)=C1O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 448.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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