TC-1827 | CAS#547741-76-4 | alpha4beta2 agonist

MedKoo Cat#: 145456 | Name: TC-1827

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-1827 is a selective alpha4beta2 agonist. TC-1827 was found to increase early LTP in a bell-shaped dose dependent manner.

Chemical Structure

TC-1827

CAS#547741-76-4

Theoretical Analysis

MedKoo Cat#: 145456

Name: TC-1827

CAS#: 547741-76-4

Chemical Formula: C10H15N3

Exact Mass: 177.1300

Molecular Weight: 177.25

Elemental Analysis: C, 67.76; H, 8.53; N, 23.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TC-1827; TC1827; TC 1827;

IUPAC/Chemical Name

(S,E)-N-methyl-5-(pyrimidin-5-yl)pent-4-en-2-amine

InChi Key

VZNTWLIIJWUCEP-SGRBOOSSSA-N

InChi Code

1S/C10H15N3/c1-9(11-2)4-3-5-10-6-12-8-13-7-10/h3,5-9,11H,4H2,1-2H3/b5-3+/t9-/m0/s1

SMILES Code

CN[C@@H](C)C\C=C\C1=CN=CN=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 177.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Grinevich VP, Papke RL, Lippiello PM, Bencherif M. Atypical antipsychotics as noncompetitive inhibitors of alpha4beta2 and alpha7 neuronal nicotinic receptors. Neuropharmacology. 2009 Aug;57(2):183-91. doi: 10.1016/j.neuropharm.2009.05.003. Epub 2009 May 28. PMID: 19481556; PMCID: PMC2999880. 2: Kroker KS, Rast G, Rosenbrock H. Differential effects of subtype-specific nicotinic acetylcholine receptor agonists on early and late hippocampal LTP. Eur J Pharmacol. 2011 Dec 5;671(1-3):26-32. doi: 10.1016/j.ejphar.2011.09.167. Epub 2011 Sep 24. PMID: 21968142. 3: Kroker KS, Moreth J, Kussmaul L, Rast G, Rosenbrock H. Restoring long-term potentiation impaired by amyloid-beta oligomers: comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists. Brain Res Bull. 2013 Jul;96:28-38. doi: 10.1016/j.brainresbull.2013.04.006. Epub 2013 Apr 29. PMID: 23639920.