Almotriptan | CAS# 154323-57-6 | Biochemical

MedKoo Cat#: 573681 | Name: Almotriptan

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Almotriptan is a triptan drug for treatment of migraine headaches. Almotriptan is a Serotonin-1b and Serotonin-1d Receptor Agonist. Binding of the drug to the receptor leads to vasoconstriction of the cranial blood vessels and thus affects the redistribution of cranial blood flow. Almotriptan significantly increases cerebral blood flow and reduces blood flow through extracerebral cranial vessels.

Chemical Structure

Almotriptan

CAS#154323-57-6 (free base)

Theoretical Analysis

MedKoo Cat#: 573681

Name: Almotriptan

CAS#: 154323-57-6 (free base)

Chemical Formula: C17H25N3O2S

Exact Mass: 335.1667

Molecular Weight: 335.47

Elemental Analysis: C, 60.87; H, 7.51; N, 12.53; O, 9.54; S, 9.56

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 250.00	2 Weeks
10mg	USD 400.00	2 Weeks

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Related CAS #

181183-52-8(malate) 154323-57-6 (free base)

Synonym

Almotriptan, LAS 31416

IUPAC/Chemical Name

Pyrrolidine, 1-(((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)sulfonyl)-

InChi Key

WKEMJKQOLOHJLZ-UHFFFAOYSA-N

InChi Code

1S/C17H25N3O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3

SMILES Code

c1c(cc2c(c[nH]c2c1)CCN(C)C)CS(N1CCCC1)(=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 335.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Abbas Z, Marihal S. Gellan gum-based mucoadhesive microspheres of almotriptan for nasal administration: Formulation optimization using factorial design, characterization, and in vitro evaluation. J Pharm Bioallied Sci. 2014 Oct;6(4):267-77. doi: 10.4103/0975-7406.142959. PubMed PMID: 25400410; PubMed Central PMCID: PMC4231387. 2: Orlandini S, Pasquini B, Stocchero M, Pinzauti S, Furlanetto S. An integrated quality by design and mixture-process variable approach in the development of a capillary electrophoresis method for the analysis of almotriptan and its impurities. J Chromatogr A. 2014 Apr 25;1339:200-9. doi: 10.1016/j.chroma.2014.02.088. Epub 2014 Mar 12. PubMed PMID: 24656544. 3: Castagno E, Lupica M, Viola S, Savino F, Miniero R. Creatin-kinase elevation after accidental ingestion of almotriptan in an 18-month-old girl. Minerva Pediatr. 2014 Feb;66(1):95-7. PubMed PMID: 24608586. 4: Lavudu P, Rani AP, Divya C, Sekharan CB. High performance liquid chromatographic analysis of almotriptan malate in bulk and tablets. Adv Pharm Bull. 2013;3(1):183-8. doi: 10.5681/apb.2013.030. Epub 2013 Feb 7. PubMed PMID: 24312833; PubMed Central PMCID: PMC3846065. 5: Nirogi R, Ajjala DR, Kandikere V, Aleti R, Pantangi HR, Srikakolapu SR, Benade V, Bhyrapuneni G, Vurimindi H. LC-MS/MS method for the quantification of almotriptan in dialysates: application to rat brain and blood microdialysis study. J Pharm Biomed Anal. 2013 Jul-Aug;81-82:160-7. doi: 10.1016/j.jpba.2013.04.008. Epub 2013 Apr 16. PubMed PMID: 23666253. 6: Negro A, Lionetto L, D'Alonzo L, Casolla B, Marsibilio F, Vignaroli G, Simmaco M, Martelletti P. Pharmacokinetic evaluation of almotriptan for the treatment of migraines. Expert Opin Drug Metab Toxicol. 2013 May;9(5):637-44. doi: 10.1517/17425255.2013.783012. Epub 2013 Apr 9. PubMed PMID: 23570251. 7: Ravikumar K, Chandu BR, Challa BR, Chandrasekhar KB. Method development and validation of almotriptan in human plasma by HPLC tandem mass spectrometry: application to pharmacokinetic study. Sci Pharm. 2012 Jun;80(2):367-78. doi: 10.3797/scipharm.1112-01. Epub 2012 Feb 27. PubMed PMID: 22896823; PubMed Central PMCID: PMC3383208. 8: Bartolini M, Giamberardino MA, Lisotto C, Martelletti P, Moscato D, Panascia B, Savi L, Pini LA, Sances G, Santoro P, Zanchin G, Omboni S, Ferrari MD, Fierro B, Brighina F. Frovatriptan versus almotriptan for acute treatment of menstrual migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study. J Headache Pain. 2012 Jul;13(5):401-6. doi: 10.1007/s10194-012-0455-4. Epub 2012 May 17. PubMed PMID: 22592864; PubMed Central PMCID: PMC3381066. 9: Oberhardt F, Fox AW. Oral sumatriptan and almotriptan--delimiting the MAOI effect. Headache. 2012 May;52(5):765-72. doi: 10.1111/j.1526-4610.2012.02113.x. Epub 2012 Mar 21. PubMed PMID: 22435741. 10: Nageswara Rao R, Guruprasad K, Gangu Naidu Ch, Raju B, Srinivas R. LC-ESI-MS/MS determination of in vivo metabolites of almotriptan in rat plasma, urine and feces: application to pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 1;891-892:44-51. doi: 10.1016/j.jchromb.2012.02.017. Epub 2012 Feb 20. PubMed PMID: 22406349.