Subasumstat, also known as TAK-981, is a potent and selective sumoylation inhibitor. TAK-981 targets and covalently binds to the small ubiquitin-like modifier (SUMO; small ubiquitin-related modifier) protein, forming an adduct with SUMO protein (TAK-981-SUMO adduct). This prevents the transfer of SUMO from the SUMO-activating enzyme (SAE) to SUMO-conjugating enzyme UBC9. This prevents SUMO conjugation to lysine residues on target proteins and abrogates many sumoylated protein-mediated cellular processes that play key roles in tumor cells, including proliferation, DNA repair, metastasis and survival.
MedKoo Cat#: 207090
Name: TAK-981
CAS#: 1858276-04-6 (free)
Chemical Formula: C25H28ClN5O5S2
Exact Mass: 577.1220
Molecular Weight: 578.10
Elemental Analysis: C, 51.94; H, 4.88; Cl, 6.13; N, 12.11; O, 13.84; S, 11.09
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 87.5 | 151.36 |
The following data is based on the product molecular weight 578.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
