AOH1160 is a potent caPCNA inhibitorr. AOH1160 exhibits selective cytotoxicity against various cancer cell lines—including neuroblastoma, breast cancer, and small-cell lung cancer—with IC₅₀ values ranging from 0.11 to 0.53 μM, while demonstrating minimal toxicity (up to 5 μM) toward nonmalignant cells such as human PBMCs, mammary epithelial cells, and small airway epithelial cells. Mechanistically, AOH1160 disrupts DNA replication, impedes homologous recombination-mediated DNA repair, induces cell-cycle arrest, and promotes apoptosis via caspase-3 and caspase-9 activation. Notably, it enhances the sensitivity of cancer cells to cisplatin, with a combination index of approximately 0.55, indicating synergistic effects.
MedKoo Cat#: 127014
Name: AOH1160
CAS#: 2089314-57-6
Chemical Formula: C25H20N2O3
Exact Mass: 396.1474
Molecular Weight: 396.45
Elemental Analysis: C, 75.74; H, 5.09; N, 7.07; O, 12.11
The following data is based on the product molecular weight 396.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
