VU 0650991 is a non-competitive antagonist of the glucagon-like peptide-1 (GLP-1) receptor, exhibiting an IC₅₀ value between 0.65 and 0.69 μM. It demonstrates over 40-fold selectivity for the GLP-1 receptor compared to glucagon receptors. By inhibiting GLP-1 receptor activity, VU 0650991 reduces insulin secretion and elevates blood glucose levels. Notably, it is both orally bioavailable and capable of penetrating the blood-brain barrier.
MedKoo Cat#: 584952
Name: VU 0650991
CAS#: 488097-06-9
Chemical Formula: C16H11ClF6N4O2
Exact Mass: 440.0475
Molecular Weight: 440.73
Elemental Analysis: C, 43.60; H, 2.52; Cl, 8.04; F, 25.86; N, 12.71; O, 7.26
The following data is based on the product molecular weight 440.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
