Nocamycin | CAS#63748-09-4 | antibiotic

MedKoo Cat#: 584864 | Name: Nocamycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nocamycin is an antitumor antibiotic structurally related to tirandamycins.

Chemical Structure

Nocamycin

CAS#63748-09-4

Theoretical Analysis

MedKoo Cat#: 584864

Name: Nocamycin

CAS#: 63748-09-4

Chemical Formula: C26H33NO9

Exact Mass: 503.2155

Molecular Weight: 503.55

Elemental Analysis: C, 62.02; H, 6.61; N, 2.78; O, 28.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Nocamycin

IUPAC/Chemical Name

Spiro(2,9-dioxabicyclo(3.3.1)nonane-8,2'-oxirane)-3'-acetic acid, 3-(6-(2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-1,3-dimethyl-6-oxo-2,4-hexadienyl)-alpha,1,4-trimethyl-6-oxo, methyl este

InChi Key

PLIWDJVEZBHXGQ-ANKZSMJWSA-N

InChi Code

InChI=1S/C26H33NO9/c1-12(7-8-16(28)19-18(30)11-27-23(19)31)9-13(2)20-14(3)21-17(29)10-26(25(5,34-20)35-21)22(36-26)15(4)24(32)33-6/h7-9,13-15,20-22,30H,10-11H2,1-6H3,(H,27,31)/b8-7+,12-9+

SMILES Code

O=C(OC)C(C)C1OC(C2(C)OC(C(C)/C=C(C)/C=C/C(C3=C(O)CNC3=O)=O)C(C)C4O2)1CC4=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 503.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mo X, Shi C, Gui C, Zhang Y, Ju J, Wang Q. Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster. Microb Cell Fact. 2017 Jun 9;16(1):100. doi: 10.1186/s12934-017-0718-5. PubMed PMID: 28599654; PubMed Central PMCID: PMC5466765. 2: Mo X, Gui C, Wang Q. Elucidation of a carboxylate O-methyltransferase NcmP in nocamycin biosynthetic pathway. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4431-4435. doi: 10.1016/j.bmcl.2017.08.010. Epub 2017 Aug 7. PubMed PMID: 28818448. 3: Horváth G, Brazhnikova MG, Konstantinova NV, Tolstykh IV, Potapova NP. The structure of nocamycin, a new antitumor antibiotic. J Antibiot (Tokyo). 1979 Jun;32(6):555-8. PubMed PMID: 468730. 4: Brazhnikova MG, Konstantinova NV, Potapova NP, Tolstykh IV. [Physicochmemical characteristics of the new antineoplastic antibiotic, nocamycin]. Antibiotiki. 1977 Jun;22(6):486-9. Russian. PubMed PMID: 18980. 5: Gauze GF, Sveshnikova MA, Ukholina RS, Komarova GN, Bazhanov VS. [Formation of a new antibiotic, nocamycin, by a culture of Nocardiopsis syringae sp. nov]. Antibiotiki. 1977 Jun;22(6):483-6. Russian. PubMed PMID: 883793.