Montirelin | CAS#90243-66-6 | thyrotropin-releasing hormone analogue

MedKoo Cat#: 597809 | Name: Montirelin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Montirelin is a particular thyrotropin-releasing hormone analogue.

Chemical Structure

Montirelin

CAS#90243-66-6

Theoretical Analysis

MedKoo Cat#: 597809

Name: Montirelin

CAS#: 90243-66-6

Chemical Formula: C17H24N6O4S

Exact Mass: 408.1580

Molecular Weight: 408.47

Elemental Analysis: C, 49.99; H, 5.92; N, 20.57; O, 15.67; S, 7.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Montirelin; CNK-603; NS 3; CNK 602A; Montirelinum;

IUPAC/Chemical Name

(3R,6R)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-6-methyl-5-oxothiomorpholine-3-carboxamide

InChi Key

RSHMQGIMHQPMEB-IXOXFDKPSA-N

InChi Code

InChI=1S/C17H24N6O4S/c1-9-15(25)22-12(7-28-9)16(26)21-11(5-10-6-19-8-20-10)17(27)23-4-2-3-13(23)14(18)24/h6,8-9,11-13H,2-5,7H2,1H3,(H2,18,24)(H,19,20)(H,21,26)(H,22,25)/t9-,11+,12+,13+/m1/s1

SMILES Code

O=C(N)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H](CS[C@@H]3C)NC3=O)=O)=O)CCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 408.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fujisawa H, Nishimura T, Kimura K. [Antigenicity study on montirelin hydrate (NS-3)]. J Toxicol Sci. 1995 Dec;20 Suppl 2:341-8. Japanese. PubMed PMID: 9019567. 2: Urayama A, Yamada S, Hirano K, Deguchi Y, Kimura R. Brain receptor binding characteristics and pharmacokinetic-pharmacodynamic analysis of thyrotropin-releasing hormone analogues. Life Sci. 2001 Dec 28;70(6):647-57. PubMed PMID: 11833715. 3: Shibata R, Ishii T, Nishiguchi Y, Iwakura K, Sumi N. [Vascular irritability study of montirelin hydrate (NS-3) injection in rabbits]. J Toxicol Sci. 1995 Dec;20 Suppl 2:335-40. Japanese. PubMed PMID: 9019566. 4: Iwakura K, Tamura H, Yamashita Y, Kitayama E, Hamasu Y, Nagasawa H, Watanabe M, Sumi N. [Mutagenicity studies of montirelin hydrate (NS-3)]. J Toxicol Sci. 1995 Dec;20 Suppl 2:325-34. Japanese. PubMed PMID: 9019565. 5: Kikumori M, Nishida I, Nishimura T, Yasuhira K, Nakai N, Nishiguchi Y, Iwakura K, Nagasawa H, Sumi N. [Single dose toxicity studies of montirelin hydrate(NS-3) in mice, rats and dogs]. J Toxicol Sci. 1995 Dec;20 Suppl 2:153-63. Japanese. PubMed PMID: 9019555. 6: Sugimoto T, Hayashi T, Okita A, Morino A. Pharmacokinetics of the new thyrotropin releasing hormone analogue montirelin hydrate. 1st communication: plasma concentrations, metabolism and excretion after a single intravenous administration to rats, dogs and monkeys. Arzneimittelforschung. 1996 Feb;46(2):106-13. PubMed PMID: 8720298. 7: Morinaga T, Furukawa S, Fujii S, Yasuhira K, Watanabe M, Sumi N. [Reproductive and developmental toxicity studies of montirelin hydrate (3)--Teratogenicity study in rabbits by intravenous administration]. J Toxicol Sci. 1995 Dec;20 Suppl 2:297-307. Japanese. PubMed PMID: 9019563. 8: Ishibashi S, Nishizawa Y, Taniguchi Y, Kikumori M, Nishimori T, Iwakura K, Sumi N. [Twenty-six-week intravenous toxicity study of montirelin hydrate (NS-3) in dogs followed by 9-week recovery test]. J Toxicol Sci. 1995 Dec;20 Suppl 2:237-57. Japanese. PubMed PMID: 9019560. 9: Sugimoto T, Hayashi T, Okita A, Morino A. Pharmacokinetics of the new thyrotropin releasing hormone analogue montirelin hydrate. 3rd communication: identification of metabolites in rat urine. Arzneimittelforschung. 1996 Feb;46(2):127-33. PubMed PMID: 8720300. 10: Kikumori M, Nishida I, Kojima M, Taniguchi Y, Yasuhira K, Ishibashi S, Iwakura K, Sumi N. [Five-week intravenous toxicity study of montirelin hydrate (NS-3) in rats followed by 4-week recovery test]. J Toxicol Sci. 1995 Dec;20 Suppl 2:171-89. Japanese. PubMed PMID: 9019557. 11: Ukai Y, Ogasawara T, Yoshikuni Y, Kimura K. [Montirelin hydrate (NS-3), a TRH analog, improved disturbance of consciousness in cats: electroencephalographical studies]. Nihon Yakurigaku Zasshi. 1996 Jun;107(6):273-84. Japanese. PubMed PMID: 8690308. 12: Mushiroi T, Shibahara R, Ukai Y, Yoshikuni Y, Kimura K. [EEG studies on the analeptic effect of montirelin hydrate (NS-3), a TRH analog, in posterior hypothalamic area-lesioned rats]. Nihon Yakurigaku Zasshi. 1996 Aug;108(2):49-63. Japanese. PubMed PMID: 8827723. 13: Harling RJ, Gopinath C, Matthiesen T, Ishibashi S, Iwakura K, Sumi N. [Four-week intravenous toxicity study of montirelin hydrate (NS-3) in dogs followed by 4-week recovery test]. J Toxicol Sci. 1995 Dec;20 Suppl 2:215-36. Japanese. Erratum in: J Toxicol Sci 1996 Feb;21(1):111. PubMed PMID: 9019559. 14: Furukawa S, Nishida I, Kikumori M, Taniguchi Y, Nishimori T, Ishibashi S, Iwakura K, Sumi N. [Twenty-six-week intravenous toxicity study of montirelin hydrate (NS-3) in rats followed by 9-week recovery test]. J Toxicol Sci. 1995 Dec;20 Suppl 2:191-213. Japanese. Erratum in: J Toxicol Sci 1996 Feb;21(1):111. PubMed PMID: 9019558. 15: Watanabe M, Toteno I, Morinaga T, Furukawa S, Kikumori M, Yasuhira K, Sumi N. [Reproductive and developmental toxicity studies of montirelin hydrate (2)--Teratogenicity and postnatal study in rats by intravenous administration]. J Toxicol Sci. 1995 Dec;20 Suppl 2:277-96. Japanese. PubMed PMID: 9019562. 16: Morinaga T, Fujii S, Kikumori M, Nishimori T, Watanabe M, Sumi N. [Reproductive and developmental toxicity studies of montirelin hydrate (4)--Perinatal and postnatal study in rats by intravenous administration]. J Toxicol Sci. 1995 Dec;20 Suppl 2:309-23. Japanese. PubMed PMID: 9019564. 17: Nishiguchi Y, Nakazawa M, Oka T, Hagidai Y, Iwakura K, Sumi N. [Single dose toxicity studies of metabolite, degradation product and impurity of montirelin hydrate (NS-3) in mice]. J Toxicol Sci. 1995 Dec;20 Suppl 2:165-9. Japanese. PubMed PMID: 9019556. 18: Morinaga T, Furukawa S, Fujii S, Kikumori M, Yasuhira K, Watanabe M, Sumi N. [Reproductive and developmental toxicity studies of montirelin hydrate (1)--Fertility study in rats by intravenous administration]. J Toxicol Sci. 1995 Dec;20 Suppl 2:259-75. Japanese. PubMed PMID: 9019561. 19: Mushiroi T, Shibahara R, Tamura M, Shimizu T, Itoh Y, Ukai Y, Yoshikuni Y, Kimura K. [Montirelin hydrate (NS-3), a TRH analog, improved the disturbance of consciousness caused by head concussion and pentobarbital in mice]. Nihon Yakurigaku Zasshi. 1996 May;107(5):237-45. Japanese. PubMed PMID: 8690305. 20: Sugimoto T, Hayashi T, Okita A, Morino A. Pharmacokinetics of the new thyrotropin releasing hormone analogue montirelin hydrate. 2nd communication: distribution and transfer into the fetus and milk after a single intravenous administration and pharmacokinetics and enzyme induction after repeated intravenous administration to rats. Arzneimittelforschung. 1996 Feb;46(2):114-27. PubMed PMID: 8720299.