Monophosphothiamine dihydrate | Monophosphothiamine | thiamine derivative | neuritis | polyneuritis | asthenic | CAS#273724-21-3

MedKoo Cat#: 124490 | Name: Monophosphothiamine dihydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Monophosphothiamine is thiamine derivative used for the treatment of neuritis, polyneuritis, asthenic conditions (weakness).

Chemical Structure

Monophosphothiamine dihydrate

CAS#273724-21-3 (2H2O)

Theoretical Analysis

MedKoo Cat#: 124490

Name: Monophosphothiamine dihydrate

CAS#: 273724-21-3 (2H2O)

Chemical Formula: C12H22ClN4O6PS

Exact Mass: 416.0700

Molecular Weight: 416.81

Elemental Analysis: C, 34.58; H, 5.32; Cl, 8.50; N, 13.44; O, 23.03; P, 7.43; S, 7.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

273724-21-3 (2H2O) 532-40-1 (free base) 635-97-2 (phosphate)

Synonym

273724-21-3; Thiamine monophosphate chloride dihydrate; Thiamine phosphate; Sineurina; THIAMINE MONOPHOSPHATE CHLORIDE*DIHYDRATE; Monophosphothiamine dihydrate; J75F6GA5EP

IUPAC/Chemical Name

3-((4-amino-2-methylpyrimidin-5-yl)methyl)-4-methyl-5-(2-(phosphonooxy)ethyl)thiazol-3-ium chloride dihydrate

InChi Key

FANVXQCOBPOPEG-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H17N4O4PS.ClH.2H2O/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13;;;/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19);1H;2*1H2

SMILES Code

CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCOP(=O)(O)O.O.O.[Cl-]

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 416.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Poupon RE, Gervaise G, Riant P, Houin G, Tillement JP. Blood thiamine and thiamine phosphate concentrations in excessive drinkers with or without peripheral neuropathy. Alcohol Alcohol. 1990;25(6):605-11. doi: 10.1093/oxfordjournals.alcalc.a045056. PMID: 1964781. 2: Rodionov DA, Leyn SA, Li X, Rodionova IA. A Novel Transcriptional Regulator Related to Thiamine Phosphate Synthase Controls Thiamine Metabolism Genes in Archaea. J Bacteriol. 2017 Jan 30;199(4):e00743-16. doi: 10.1128/JB.00743-16. PMID: 27920295; PMCID: PMC5287396.