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MedKoo Cat#: 531660 | Name: CCG-50014
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CCG-50014 is a potent small molecule inhibitor of regulator of G-protein signaling protein 4 (RGS4).

Chemical Structure

CCG-50014
CCG-50014
CAS#883050-24-6

Theoretical Analysis

MedKoo Cat#: 531660

Name: CCG-50014

CAS#: 883050-24-6

Chemical Formula: C16H13FN2O2S

Exact Mass: 316.0682

Molecular Weight: 316.35

Elemental Analysis: C, 60.75; H, 4.14; F, 6.01; N, 8.86; O, 10.11; S, 10.13

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 2 Weeks
10mg USD 450.00 2 Weeks
25mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
CCG-50014; CCG 50014; CCG50014.
IUPAC/Chemical Name
4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
InChi Key
QUIIIYITNGOFEI-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
SMILES Code
O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 316.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yoon SY, Woo J, Park JO, Choi EJ, Shin HS, Roh DH, Kim KS. Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test. Anesth Analg. 2015 Mar;120(3):671-7. doi: 10.1213/ANE.0000000000000607. PubMed PMID: 25695583. 2: Vashisth H, Storaska AJ, Neubig RR, Brooks CL 3rd. Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. ACS Chem Biol. 2013 Dec 20;8(12):2778-84. doi: 10.1021/cb400568g. PubMed PMID: 24093330; PubMed Central PMCID: PMC3876963. 3: Blazer LL, Zhang H, Casey EM, Husbands SM, Neubig RR. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry. 2011 Apr 19;50(15):3181-92. doi: 10.1021/bi1019622. PubMed PMID: 21329361; PubMed Central PMCID: PMC3090679.