Synonym
Nocardamine; Desferrioxamine E; Proferrioxamine E
IUPAC/Chemical Name
1,12,23-trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone
InChi Key
NHKCCADZVLTPPO-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H48N6O9/c34-22-10-14-26(38)32(41)20-8-3-6-18-30-24(36)12-15-27(39)33(42)21-9-2-5-17-29-23(35)11-13-25(37)31(40)19-7-1-4-16-28-22/h40-42H,1-21H2,(H,28,34)(H,29,35)(H,30,36)
SMILES Code
O=C(CCC(N(O)CCCCCNC(CCC1=O)=O)=O)NCCCCCN(O)C(CCC(NCCCCCN1O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
600.71
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lopez, J.A.V., Nogawa, T., Futamura, Y., et al. Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647. J. Antibiot. (Tokyo) 72(12), 991-995 (2019).
2: Ishida, S., Arai, M., Niikawa, H., et al. Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium species. Biol. Pharm. Bull. 34(6), 917-920 (2011).
3: Kalinovskaya, N.I., Romaneko, L.A., Irisawa, T., et al. Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activity. Microbiol. Res. 166(8), 654-661 (2011).
4: Matsubara, K., Sakuda, S., Tanaka, M., et al. Morphological changes in insect BM-N4 cells induced by nocardamine. Biosci. Biotechnol. Biochem. 62(10), 2049-2051 (1998).
