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MedKoo Cat#: 584772 | Name: Mozenavir

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mozenavir, also known as DMP-450, is an antiretroviral.

Chemical Structure

Mozenavir
Mozenavir
CAS#174391-92-5 (free base)

Theoretical Analysis

MedKoo Cat#: 584772

Name: Mozenavir

CAS#: 174391-92-5 (free base)

Chemical Formula: C33H36N4O3

Exact Mass: 536.2787

Molecular Weight: 536.68

Elemental Analysis: C, 73.86; H, 6.76; N, 10.44; O, 8.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
174391-92-5 (free base) 177932-89-7 (dimesylate)
Synonym
Mozenavir; DMP-450; DMP 450; DMP450;
IUPAC/Chemical Name
(4R,5S,6S,7R)-1,3-Bis(3-aminobenzyl)-4,7-dibenzylhexahydro-5,6-dihydroxy-2H-1,3-diazepin-2-one
InChi Key
KYRSNWPSSXSNEP-ZRTHHSRSSA-N
InChi Code
InChI=1S/C33H36N4O3/c34-27-15-7-13-25(17-27)21-36-29(19-23-9-3-1-4-10-23)31(38)32(39)30(20-24-11-5-2-6-12-24)37(33(36)40)22-26-14-8-16-28(35)18-26/h1-18,29-32,38-39H,19-22,34-35H2/t29-,30-,31+,32+/m1/s1
SMILES Code
O=C1N(CC2=CC=CC(N)=C2)[C@H](CC3=CC=CC=C3)[C@H](O)[C@@H](O)[C@@H](CC4=CC=CC=C4)N1CC5=CC=CC(N)=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 536.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: De Clercq E. New developments in anti-HIV chemotherapy. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):258-75. Review. PubMed PMID: 12084468. 2: De Clercq E. New anti-HIV agents and targets. Med Res Rev. 2002 Nov;22(6):531-65. Review. PubMed PMID: 12369088. 3: De Clercq E. Highlights in the development of new antiviral agents. Mini Rev Med Chem. 2002 Apr;2(2):163-75. Review. PubMed PMID: 12370077. 4: Moyle G. Overcoming obstacles to the success of protease inhibitors in highly active antiretroviral therapy regimens. AIDS Patient Care STDS. 2002 Dec;16(12):585-97. Review. PubMed PMID: 12542932. 5: Yoshimura K, Maeda K. [New HIV-1 protease inhibitors in development]. Nihon Rinsho. 2002 Apr;60(4):780-3. Review. Japanese. PubMed PMID: 11968788. 6: Hensen C, Hermann JC, Nam K, Ma S, Gao J, Höltje HD. A combined QM/MM approach to protein--ligand interactions: polarization effects of the HIV-1 protease on selected high affinity inhibitors. J Med Chem. 2004 Dec 30;47(27):6673-80. PubMed PMID: 15615516.