MedKoo Cat#: 563112 | Name: SW120

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SW120 is a fluorescent sigma-2 selective ligand.

Chemical Structure

SW120
SW120
CAS#1421931-14-7

Theoretical Analysis

MedKoo Cat#: 563112

Name: SW120

CAS#: 1421931-14-7

Chemical Formula: C33H48N6O7

Exact Mass: 640.3584

Molecular Weight: 640.78

Elemental Analysis: C, 61.86; H, 7.55; N, 13.12; O, 17.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SW120; SW-120; SW 120;
IUPAC/Chemical Name
(2,5-Dimethoxy-phenyl)-carbamic acid 9-[10-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-decyl]-9-aza-bicyclo[3.3.1]non-3-yl ester
InChi Key
BHCVRPVATGCNGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H48N6O7/c1-43-26-14-16-31(44-2)29(22-26)36-33(40)45-27-20-24-12-11-13-25(21-27)37(24)19-10-8-6-4-3-5-7-9-18-34-28-15-17-32(39(41)42)38-30(28)23-35-46-38/h14-17,22-25,27,34-35H,3-13,18-21H2,1-2H3,(H,36,40)
SMILES Code
O=C(OC1CC(N2CCCCCCCCCCNC3=CC=C([N+]([O-])=O)N4C3=CNO4)CCCC2C1)NC5=CC(OC)=CC=C5OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 640.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bean DC, Wigmore SM, Wareham DW. Draft Genome Sequence of Staphylococcus cohnii subsp. urealyticus Isolated from a Healthy Dog. Genome Announc. 2017 Feb 16;5(7). pii: e01628-16. doi: 10.1128/genomeA.01628-16. PubMed PMID: 28209829; PubMed Central PMCID: PMC5313621. 2: Zeng C, Garg N, Mach RH. The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells. Mol Imaging Biol. 2016 Apr;18(2):172-9. doi: 10.1007/s11307-015-0891-z. PubMed PMID: 26335282. 3: Zeng C, Vangveravong S, Jones LA, Hyrc K, Chang KC, Xu J, Rothfuss JM, Goldberg MP, Hotchkiss RS, Mach RH. Characterization and evaluation of two novel fluorescent sigma-2 receptor ligands as proliferation probes. Mol Imaging. 2011 Dec;10(6):420-33. PubMed PMID: 22201533; PubMed Central PMCID: PMC4426860. 4: Xu J, Zeng C, Chu W, Pan F, Rothfuss JM, Zhang F, Tu Z, Zhou D, Zeng D, Vangveravong S, Johnston F, Spitzer D, Chang KC, Hotchkiss RS, Hawkins WG, Wheeler KT, Mach RH. Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun. 2011 Jul 5;2:380. doi: 10.1038/ncomms1386. PubMed PMID: 21730960; PubMed Central PMCID: PMC3624020. 5: Haller JL, Panyutin I, Chaudhry A, Zeng C, Mach RH, Frank JA. Sigma-2 receptor as potential indicator of stem cell differentiation. Mol Imaging Biol. 2012 Jun;14(3):325-35. doi: 10.1007/s11307-011-0493-3. PubMed PMID: 21614680; PubMed Central PMCID: PMC3164741. 6: Törnsten A, Jeon JT, Alexander LJ, Andersson L, Chowdhary BP. Physical ordering of six YACs from the RN region in pigs. Anim Genet. 1998 Aug;29(4):319-21. PubMed PMID: 9745672. 7: Reinsch N, Looft C, Rudat I, Kalm E. The Kiel RN experiment: final porcine chromosome 15 mapping results. J Anim Breed Genet. 1997 Jan 12;114(1-6):133-42. doi: 10.1111/j.1439-0388.1997.tb00500.x. PubMed PMID: 21395810. 8: Milan D, Woloszyn N, Yerle M, Le Roy P, Bonnet M, Riquet J, Lahbib-Mansais Y, Caritez JC, Robic A, Sellier P, Elsen JM, Gellin J. Accurate mapping of the "acid meat" RN gene on genetic and physical maps of pig chromosome 15. Mamm Genome. 1996 Jan;7(1):47-51. PubMed PMID: 8903728.