MedKoo Cat#: 341369 | Name: Bromopride free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bromopride free base is a dopamine antagonist with prokinetic properties widely used as an antiemetic

Chemical Structure

Bromopride free base
Bromopride free base
CAS#4093-35-0 (free base)

Theoretical Analysis

MedKoo Cat#: 341369

Name: Bromopride free base

CAS#: 4093-35-0 (free base)

Chemical Formula: C14H22BrN3O2

Exact Mass: 343.0895

Molecular Weight: 344.25

Elemental Analysis: C, 48.85; H, 6.44; Br, 23.21; N, 12.21; O, 9.29

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
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Synonym
Bromopride free base; VAL 13081; VA- 13081; VAL13081.
IUPAC/Chemical Name
4-Amino-5-bromo-N-(2-(diethylamino)ethyl)-o-anisamide
InChi Key
GIYAQDDTCWHPPL-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H22BrN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
SMILES Code
COC1=CC(N)=C(Br)C=C1C(NCCN(CC)CC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Huebner EA, Budel S, Jiang Z, Omura T, Ho TS, Barrett L, Merkel JS, Pereira LM, Andrews NA, Wang X, Singh B, Kapur K, Costigan M, Strittmatter SM, Woolf CJ. Diltiazem Promotes Regenerative Axon Growth. Mol Neurobiol. 2018 Sep 19. doi: 10.1007/s12035-018-1349-5. [Epub ahead of print] PubMed PMID: 30232777. 2: Epifanio M, Portela JL, Piva JP, Ferreira CHT, Sarria EE, Mattiello R. Bromopride, metoclopramide, or ondansetron for the treatment of vomiting in the pediatric emergency department: a randomized controlled trial. J Pediatr (Rio J). 2018 Jan - Feb;94(1):62-68. doi: 10.1016/j.jped.2017.06.004. Epub 2017 Aug 1. PubMed PMID: 28778685. 3: Silva SM, Jerônimo MS, Silva-Pereira I, Bocca AL, Sousa JB. Effects of bromopride on expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study. Braz J Med Biol Res. 2014 Oct;47(10):911-6. Epub 2014 Aug 15. PubMed PMID: 25140813; PubMed Central PMCID: PMC4181227. 4: Lima LS, Los Weinert P, Pezza L, Pezza HR. Sensitive flow-injection spectrophotometric analysis of bromopride. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Dec 10;133:597-604. doi: 10.1016/j.saa.2014.06.027. Epub 2014 Jun 14. PubMed PMID: 24992919. 5: Dunne CE, Bushee JL, Argikar UA. Metabolism of bromopride in mouse, rat, rabbit, dog, monkey, and human hepatocytes. Drug Metab Pharmacokinet. 2013;28(6):453-61. Epub 2013 Apr 23. PubMed PMID: 23615565. 6: Morais PH, Silva NG, Oliveira MV, Brandão AM, Silva SM, Carneiro FP, Sousa JB. Effects of prokinetic drugs on the abdominal wall wound healing of rats submitted to segmental colectomy and colonic anastomosis. Acta Cir Bras. 2012 Jul;27(7):448-53. PubMed PMID: 22760828. 7: Silva SM, Carneiro FP, Oliveira PG, Morais PH, Silva NG, Sousa JB. Effects of bromopride on the healing of left colonic anastomoses in rats with induced abdominal sepsis. Acta Cir Bras. 2012 Jun;27(6):370-5. PubMed PMID: 22666753. 8: Marques e Silva S, Ferreira VM, Carneiro FP, Feres O, de Oliveira PG, de Sousa JB. Effects of bromopride on the healing of left colon anastomoses of rats. Rev Col Bras Cir. 2011 Nov-Dec;38(6):429-34. English, Portuguese. PubMed PMID: 22267142. 9: Oliveira MV, Brandão AM, Morais PH, Silva NG, Silva SM, Carneiro FP, Sousa JB. Effects of bromopride on abdominal wall healing with induced peritoneal sepsis after segmental colectomy and colonic anastomosis in rats. Acta Cir Bras. 2011 Dec;26(6):433-7. PubMed PMID: 22042104. 10: Martins IS, Pellegrino FL, Freitas Ad, Santos Mda S, Ferraiuoli GI, Vasques MR, Amorim EL, Oliveira S, Nouér SA, Cardoso FL, Mascarenhas LA, Magalhães AC, Cleinman IB, Figueiredo AM, Moreira BM. Case-crossover study of Burkholderia cepacia complex bloodstream infection associated with contaminated intravenous bromopride. Infect Control Hosp Epidemiol. 2010 May;31(5):516-21. doi: 10.1086/651667. PubMed PMID: 20205589. 11: Lira RP, Moraes LF, Oliveira Júnior Md, Melo AL, Vasconcelos MS. Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography. Arq Bras Oftalmol. 2007 Jan-Feb;70(1):105-8. PubMed PMID: 17505728. 12: Nazare P, Massaroti P, Duarte LF, Campos DR, Marchioretto MA, Bernasconi G, Calafatti S, Barros FA, Meurer EC, Pedrazzoli J, Moraes LA. Validated method for determination of bromopride in human plasma by liquid chromatography--electrospray tandem mass spectrometry: application to the bioequivalence study. J Mass Spectrom. 2005 Sep;40(9):1197-202. PubMed PMID: 16127659. 13: Teixeira FV, Novaretti TM, Pilon B, Pereira PG, Breda MF. Mirtazapine (Remeron) as treatment for non-mechanical vomiting after gastric bypass. Obes Surg. 2005 May;15(5):707-9. PubMed PMID: 15946465. 14: Tonini M, Cipollina L, Poluzzi E, Crema F, Corazza GR, De Ponti F. Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Aliment Pharmacol Ther. 2004 Feb 15;19(4):379-90. Review. PubMed PMID: 14871277. 15: Buzo Sánchez LG, Artacho Criado S, Navarro Pulido AM, Orta Cuevas JC. [Domperidone: an alternative to orthopramides in the case of adverse reactions in the central nervous system]. Med Clin (Barc). 1996 Sep 14;107(8):317-8. Spanish. PubMed PMID: 8965498. 16: Nasello AG, Gidali D, de Sá-Rocha LC, Felicio LF. Differential effects of bromopride and domperidone on cholinesterase activity in rat tissues. Life Sci. 1995;56(3):151-6. PubMed PMID: 7823770. 17: Calpena AC, Blanes C, Moreno J, Obach R, Domenech J. A comparative in vitro study of transdermal absorption of antiemetics. J Pharm Sci. 1994 Jan;83(1):29-33. PubMed PMID: 8138905. 18: Ullrich KJ, Rumrich G, David C, Fritzsch G. Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines. Pflugers Arch. 1993 Nov;425(3-4):280-99. PubMed PMID: 8309790. 19: Canepa G, Di Somma C, Arnulfo G, Frascio M, Berti Riboli E. [A retrospective study on the efficacy of the treatment of functional dyspepsia. An evaluation of 166 cases]. Minerva Med. 1991 Jun;82(6):371-3. Italian. PubMed PMID: 2067709. 20: Nasello AG, Vanzeler ML, Felicio LF. A comparison of bromopride and domperidone effects on rat conditioned avoidance and motor activity. Pharmacol Toxicol. 1991 Jan;68(1):46-50. PubMed PMID: 2008411.