MedKoo Cat#: 525183 | Name: GSK-1004723

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-1004723 is a novel, dual histamine H(1) and H(3) receptor antagonist. It represents a potential novel therapy for allergic rhinitis.

Chemical Structure

GSK-1004723
GSK-1004723
CAS#955359-72-5

Theoretical Analysis

MedKoo Cat#: 525183

Name: GSK-1004723

CAS#: 955359-72-5

Chemical Formula: C39H49ClN4O2

Exact Mass: 640.3544

Molecular Weight: 641.28

Elemental Analysis: C, 73.04; H, 7.70; Cl, 5.53; N, 8.74; O, 4.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
955359-75-8 (HCl)
Synonym
GSK-1004723; GSK1004723; GSK 1004723;
IUPAC/Chemical Name
(R)-2-((1-(4-(4-(3-(azepan-1-yl)propoxy)phenyl)butyl)pyrrolidin-2-yl)methyl)-4-(4-chlorobenzyl)phthalazin-1(2H)-one
InChi Key
YANGEESWIGIKOP-UUWRZZSWSA-N
InChi Code
1S/C39H49ClN4O2/c40-33-19-15-32(16-20-33)29-38-36-13-3-4-14-37(36)39(45)44(41-38)30-34-12-9-27-43(34)26-8-5-11-31-17-21-35(22-18-31)46-28-10-25-42-23-6-1-2-7-24-42/h3-4,13-22,34H,1-2,5-12,23-30H2/t34-/m1/s1
SMILES Code
O=C1N(C[C@@H]2N(CCCCC3=CC=C(OCCCN4CCCCCC4)C=C3)CCC2)N=C(CC5=CC=C(Cl)C=C5)C6=C1C=CC=C6
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 955359-75-8(GSK-1004723D HCl) 955359-72-5(GSK-1004723D Free base)

Preparing Stock Solutions

The following data is based on the product molecular weight 641.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Daley-Yates P, Ambery C, Sweeney L, Watson J, Oliver A, McQuade B. The efficacy and tolerability of two novel H(1)/H(3) receptor antagonists in seasonal allergic rhinitis. Int Arch Allergy Immunol. 2012;158(1):84-98. doi: 10.1159/000329738. Epub 2011 Dec 29. Review. PubMed PMID: 22212854. 2: Slack RJ, Russell LJ, Hall DA, Luttmann MA, Ford AJ, Saunders KA, Hodgson ST, Connor HE, Browning C, Clark KL. Pharmacological characterization of GSK1004723, a novel, long-acting antagonist at histamine H(1) and H(3) receptors. Br J Pharmacol. 2011 Nov;164(6):1627-41. doi: 10.1111/j.1476-5381.2011.01285.x. PubMed PMID: 22022805; PubMed Central PMCID: PMC3230810. 3: Norman P. New H1/H3 antagonists for treating allergic rhinitis: WO2010094643. Expert Opin Ther Pat. 2011 Mar;21(3):425-9. doi: 10.1517/13543776.2011.536533. Review. PubMed PMID: 21342057.