NPS R-467 | CAS# 148717-56-0 | Calcimimetic compound

MedKoo Cat#: 414514 | Name: NPS R-467

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NPS R-467 is a Calcimimetic compound.

Chemical Structure

NPS R-467

CAS#148717-56-0

Theoretical Analysis

MedKoo Cat#: 414514

Name: NPS R-467

CAS#: 148717-56-0

Chemical Formula: C18H23NO

Exact Mass: 269.1780

Molecular Weight: 269.39

Elemental Analysis: C, 80.26; H, 8.61; N, 5.20; O, 5.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NPS R-467; NPSR-467; NPS-R-467; MC0100; MC-0100; MC 0100

IUPAC/Chemical Name

(R)-N-(1-(3-methoxyphenyl)ethyl)-3-phenylpropan-1-amine

InChi Key

WOPAHKKTEVUGOE-OAHLLOKOSA-N

InChi Code

InChI=1S/C18H23NO/c1-15(17-11-6-12-18(14-17)20-2)19-13-7-10-16-8-4-3-5-9-16/h3-6,8-9,11-12,14-15,19H,7,10,13H2,1-2H3/t15-/m1/s1

SMILES Code

COc1cc([C@H](NCCCc2ccccc2)C)ccc1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 269.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gu J, Ren Z, Zhao J, Peprah FA, Xie Y, Cheng D, Wang Y, Liu H, Chu Wong CK, Zhou Y, Shi H. Calcimimetic compound NPS R-467 protects against chronic cadmium- induced mouse kidney injury by restoring autophagy process. Ecotoxicol Environ Saf. 2020 Feb;189:110052. doi: 10.1016/j.ecoenv.2019.110052. Epub 2019 Dec 9. PMID: 31830606. 2: Pattaragarn A, Fox J, Alon US. Effect of the calcimimetic NPS R-467 on furosemide-induced nephrocalcinosis in the young rat. Kidney Int. 2004 May;65(5):1684-9. doi: 10.1111/j.1523-1755.2004.00564.x. PMID: 15086907. 3: Zhang Z, Jiang Y, Quinn SJ, Krapcho K, Nemeth EF, Bai M. L-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium- sensing receptor through distinct sites. J Biol Chem. 2002 Sep 13;277(37):33736-41. doi: 10.1074/jbc.M200978200. Epub 2002 Jul 11. PMID: 12114500. 4: Roussanne MC, Lieberherr M, Souberbielle JC, Sarfati E, Drüeke T, Bourdeau A. Human parathyroid cell proliferation in response to calcium, NPS R-467, calcitriol and phosphate. Eur J Clin Invest. 2001 Jul;31(7):610-6. doi: 10.1046/j.1365-2362.2001.00809.x. PMID: 11454016. 5: Wang X, Wang N, Hu J. [Effect of NPS R-467 on PTH secretion of cultured parathyroid cells from secondary hyperparathyroidism patients]. Zhonghua Yi Xue Za Zhi. 2001 Nov 10;81(21):1321-3. Chinese. PMID: 16200727. 6: Messa P, Como G, Brezzi B. I calciomimetici [Calcimimetics]. G Ital Nefrol. 2006 Jan-Feb;23(1):12-21. Italian. PMID: 16521071. 7: Hammerland LG, Garrett JE, Hung BC, Levinthal C, Nemeth EF. Allosteric activation of the Ca2+ receptor expressed in Xenopus laevis oocytes by NPS 467 or NPS 568. Mol Pharmacol. 1998 Jun;53(6):1083-8. PMID: 9614212. 8: Straub SG, Kornreich B, Oswald RE, Nemeth EF, Sharp GW. The calcimimetic R-467 potentiates insulin secretion in pancreatic beta cells by activation of a nonspecific cation channel. J Biol Chem. 2000 Jun 23;275(25):18777-84. doi: 10.1074/jbc.M000090200. PMID: 10751384. 9: Martino NA, Lange-Consiglio A, Cremonesi F, Valentini L, Caira M, Guaricci AC, Ambruosi B, Sciorsci RL, Lacalandra GM, Reshkin SJ, Dell'Aquila ME. Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cells. PLoS One. 2011 Mar 17;6(3):e17714. doi: 10.1371/journal.pone.0017714. PMID: 21437284; PMCID: PMC3060090. 10: Okada Y, Imendra KG, Miyazaki T, Hotokezaka H, Fujiyama R, Zeredo JL, Toda K. A calcium-receptor agonist induces gustatory neural responses in bullfrogs. Cell Mol Neurobiol. 2007 Sep;27(6):771-81. doi: 10.1007/s10571-007-9171-z. Epub 2007 Jul 17. PMID: 17636404.