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MedKoo Cat#: 593024 | Name: Prednisolone sodium metazoate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prednisolone sodium metazoate is used in the treatment of Inflammatory Bowel Disease, Ulcerative Colitis, and GI Disorders.

Chemical Structure

Prednisolone sodium metazoate
CAS#630-67-1 (sodium metazoate)

Theoretical Analysis

MedKoo Cat#: 593024

Name: Prednisolone sodium metazoate

CAS#: 630-67-1 (sodium metazoate)

Chemical Formula: C28H31NaO9S

Exact Mass: 566.1586

Molecular Weight: 566.60

Elemental Analysis: C, 59.36; H, 5.52; Na, 4.06; O, 25.41; S, 5.66

Price and Availability

Size Price Availability Quantity
100mg USD 330.00
1g USD 1,650.00
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Related CAS #
52-21-1 (acetate) 72064-79-0 (valerate acetate) 630-67-1 (sodium metazoate) 125-02-0 (Na+ phosphate) 50-24-8 (free)
Synonym
Prednisolone sodium metazoate
IUPAC/Chemical Name
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-, 21-(m-sulfobenzoate), monosodium salt
InChi Key
RWFZSORKWFPGNE-VDYYWZOJSA-M
InChi Code
InChI=1S/C28H32O9S.Na/c1-26-10-8-18(29)13-17(26)6-7-20-21-9-11-28(33,27(21,2)14-22(30)24(20)26)23(31)15-37-25(32)16-4-3-5-19(12-16)38(34,35)36;/h3-5,8,10,12-13,20-22,24,30,33H,6-7,9,11,14-15H2,1-2H3,(H,34,35,36);/q;+1/p-1/t20-,21-,22-,24+,26-,27-,28-;/m0./s1
SMILES Code
C[C@@]12[C@](C(COC(C3=CC=CC(S(=O)([O-])=O)=C3)=O)=O)(O)CC[C@@]1([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Prednisolone sodium metazoate is used in the treatment of Inflammatory Bowel Disease, Ulcerative Colitis, and GI Disorders.
In vitro activity:
This study reports here a study of Prednisolone treatment using as a model a leukemia cell line with subsequent investigation of resistance-related gene expression. This study analyzed effects of increasing doses of Prednisolone on ALL cell survival and growth, and monitored immediate effects on gene expression through gene expression assays. Upon treatment with escalating Prednisolone concentration, this study observed a gradual decline in cell survival. Prednisolone competitively induces MCL1 expression. Reference: Adv Exp Med Biol. 2021;1339:147-160. https://pubmed.ncbi.nlm.nih.gov/35023102/
In vivo activity:
This study evaluated the effect of in vivo administration of prednisolone on Escherichia coli lipopolysaccharide endotoxin (LPS)-induced increases in plasma RNI and neutrophil mRNA for NOS II and production of RNI in the rat. This study shows that LPS rapidly induces mRNA for NOS II and production of RNI (NO2- and NO3- anion) in rat neutrophils within 2 hr after in vivo administration of a sublethal dose of 0.5 mg/kg, i.v. A pharmacologic dose of prednisolone (50 micrograms/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppressed LPS-stimulated mRNA for NOS II. 3-Amino, 1,2,4-triazine inhibited NO2- and NO3- production without affecting gene expression for NOS II. Reference: Proc Soc Exp Biol Med. 1994 Mar;205(3):220-9. https://pubmed.ncbi.nlm.nih.gov/7513433/
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 566.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. G L, Adamaki M, Hatziagapiou K, Geronikolou SA, Tsartsalis AN, Vlahopoulos S. Early and Very Early GRIM19 and MCL1 Expression Are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line. Adv Exp Med Biol. 2021;1339:147-160. doi: 10.1007/978-3-030-78787-5_20. PMID: 35023102. 2. Li C, Yang P, Liu B, Bu J, Liu H, Guo J, Hasegawa T, Si H, Li M. Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3β/β-catenin pathway. J Mol Histol. 2021 Oct;52(5):1081-1095. doi: 10.1007/s10735-021-10006-0. Epub 2021 Jul 23. PMID: 34297260. 3. Rioja I, Bush KA, Buckton JB, Dickson MC, Life PF. Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment. Clin Exp Immunol. 2004 Jul;137(1):65-73. doi: 10.1111/j.1365-2249.2004.02499.x. PMID: 15196245; PMCID: PMC1809073. 4. Kolls J, Xie J, LeBlanc R, Malinski T, Nelson S, Summer W, Greenberg SS. Rapid induction of messenger RNA for nitric oxide synthase II in rat neutrophils in vivo by endotoxin and its suppression by prednisolone. Proc Soc Exp Biol Med. 1994 Mar;205(3):220-9. doi: 10.3181/00379727-205-43700. PMID: 7513433.
In vitro protocol:
1. G L, Adamaki M, Hatziagapiou K, Geronikolou SA, Tsartsalis AN, Vlahopoulos S. Early and Very Early GRIM19 and MCL1 Expression Are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line. Adv Exp Med Biol. 2021;1339:147-160. doi: 10.1007/978-3-030-78787-5_20. PMID: 35023102. 2. Li C, Yang P, Liu B, Bu J, Liu H, Guo J, Hasegawa T, Si H, Li M. Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3β/β-catenin pathway. J Mol Histol. 2021 Oct;52(5):1081-1095. doi: 10.1007/s10735-021-10006-0. Epub 2021 Jul 23. PMID: 34297260.
In vivo protocol:
1. Rioja I, Bush KA, Buckton JB, Dickson MC, Life PF. Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment. Clin Exp Immunol. 2004 Jul;137(1):65-73. doi: 10.1111/j.1365-2249.2004.02499.x. PMID: 15196245; PMCID: PMC1809073. 2. Kolls J, Xie J, LeBlanc R, Malinski T, Nelson S, Summer W, Greenberg SS. Rapid induction of messenger RNA for nitric oxide synthase II in rat neutrophils in vivo by endotoxin and its suppression by prednisolone. Proc Soc Exp Biol Med. 1994 Mar;205(3):220-9. doi: 10.3181/00379727-205-43700. PMID: 7513433.
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PLoS One. 2018 Jul 19;13(7):e0200849. doi: 10.1371/journal.pone.0200849. eCollection 2018. PubMed PMID: 30024940; PubMed Central PMCID: PMC6053203. 4: Royle KL, Gregory WM, Cairns DA, Bell SE, Cook G, Owen RG, Drayson MT, Davies FE, Jackson GH, Morgan GJ, Child JA. Quality of life during and following sequential treatment of previously untreated patients with multiple myeloma: findings of the Medical Research Council Myeloma IX randomised study. Br J Haematol. 2018 Jul 9. doi: 10.1111/bjh.15459. [Epub ahead of print] PubMed PMID: 29984830. 5: Shimoji M, Ramaswamy B, Shukoor MI, Benhal P, Broda A, Kulkarni S, Malik P, McCaffrey B, Lafond JF, Nacev A, Weinberg IN, Shapiro B, Depireux DA. Toxicology study for magnetic injection of prednisolone into the rat cochlea. Eur J Pharm Sci. 2018 Jun 19. pii: S0928-0987(18)30267-7. doi: 10.1016/j.ejps.2018.06.011. [Epub ahead of print] PubMed PMID: 29933075. 6: Al-Qaim FF, Mussa ZH, Yuzir A. Development and validation of a comprehensive solid-phase extraction method followed by LC-TOF/MS for the analysis of eighteen pharmaceuticals in influent and effluent of sewage treatment plants. Anal Bioanal Chem. 2018 Aug;410(20):4829-4846. doi: 10.1007/s00216-018-1120-9. Epub 2018 May 28. PubMed PMID: 29806068. 7: Tomazi T, Lopes TAF, Masson V, Swinkels JM, Santos MV. Randomized noninferiority field trial evaluating cephapirin sodium for treatment of nonsevere clinical mastitis. J Dairy Sci. 2018 Aug;101(8):7334-7347. doi: 10.3168/jds.2017-14002. Epub 2018 May 16. PubMed PMID: 29778482. 8: Verstappen EMJ, Maaskant-Braat AJG, Scheltinga MR. Bilateral breast calciphylaxis in a patient who survived earlier extensive tissue necrosis 5 years previously: A case report. Int J Surg Case Rep. 2018;48:22-25. doi: 10.1016/j.ijscr.2018.04.035. Epub 2018 May 7. PubMed PMID: 29775967; PubMed Central PMCID: PMC6043165. 9: Lee HR, Kim TH, Oh SH, Lee JH. Prednisolone-loaded coatable polyvinyl alcohol/alginate hydrogel for the treatment of atopic dermatitis. J Biomater Sci Polym Ed. 2018 Sep;29(13):1612-1624. doi: 10.1080/09205063.2018.1477317. Epub 2018 May 23. PubMed PMID: 29764304. 10: Yamada T, Fukui M, Kashiwagi T, Arai T, Itokawa N, Atsukawa M, Shimizu A, Tsuruoka S. A Case of Sjögren's Syndrome Complicated with Interstitial Nephritis and Delayed Onset Autoimmune Hepatitis. J Nippon Med Sch. 2018;85(2):117-123. doi: 10.1272/jnms.2018_85-18. PubMed PMID: 29731495. 11: Zeugswetter FK, Haninger T. Prednisolone dosages in Addisonian dogs after integration of ACTH measurement into treatment surveillance. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2018 Apr;46(2):90-96. doi: 10.15654/TPK-170668. Epub 2018 May 4. PubMed PMID: 29727896. 12: Sasaki T, Ide T, Toda I, Kato N. Amnwiotic Membrane Transplantation as a Treatment for Sterile Infiltration and Corneal Melting after Corneal Crosslinking for Keratoconus. Case Rep Ophthalmol. 2018 Mar 2;9(1):185-189. doi: 10.1159/000487074. eCollection 2018 Jan-Apr. PubMed PMID: 29681834; PubMed Central PMCID: PMC5903102. 13: Baartman BJ, Gans R, Goshe J. Prednisolone versus dexamethasone for prevention of pseudophakic cystoid macular edema. Can J Ophthalmol. 2018 Apr;53(2):131-134. doi: 10.1016/j.jcjo.2017.08.012. PubMed PMID: 29631823. 14: El Gammal RN, Hammouda MEA, El-Wasseef DR, El-Ashry SM. Simultaneous Determination of Gatifloxacin and Prednisolone in their Bulk Powder, Synthetic Mixture and Their Combined Ophthalmic Preparation Using Micellar Liquid Chromatography. J Chromatogr Sci. 2018 Apr 1;56(4):367-374. doi: 10.1093/chromsci/bmy011. PubMed PMID: 29474545. 15: Weiner SM. [Renal Involvement in Connective Tissue Diseases]. Dtsch Med Wochenschr. 2018 Jan;143(2):89-100. doi: 10.1055/s-0043-106563. Epub 2018 Jan 22. German. PubMed PMID: 29359289. 16: Wystrychowski G, Wystrychowski W, Grzeszczak W, Więcek A, Król R, Wystrychowski A. Pentoxifylline and Methylprednisolone Additively Alleviate Kidney Failure and Prolong Survival of Rats after Renal Warm Ischemia-Reperfusion. Int J Mol Sci. 2018 Jan 11;19(1). pii: E221. doi: 10.3390/ijms19010221. PubMed PMID: 29324683; PubMed Central PMCID: PMC5796170. 17: Kumari A, Jain A, Hurkat P, Tiwari A, Jain SK. Eudragit S100 coated microsponges for Colon targeting of prednisolone. Drug Dev Ind Pharm. 2018 Jun;44(6):902-913. doi: 10.1080/03639045.2017.1420079. Epub 2018 Jan 3. PubMed PMID: 29260916. 18: Porcaro F, Paglietti MG, Diamanti A, Petreschi F, Schiavino A, Negro V, Pecora V, Fiocchi A, Cutrera R. Anaphylactic shock with methylprednisolone sodium succinate in a child with short bowel syndrome and cow's milk allergy. Ital J Pediatr. 2017 Nov 17;43(1):104. doi: 10.1186/s13052-017-0422-4. PubMed PMID: 29149860; PubMed Central PMCID: PMC5693518. 19: Rebedew DL. Is Central Pontine Myelinolysis Reversible? WMJ. 2016 Dec;115(6):326-8. 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