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MedKoo Cat#: 591186 | Name: ADL-08-0011

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ADL-08-0011 is an alvimopan metabolite.

Chemical Structure

ADL-08-0011
CAS#156130-41-5 (free base)

Theoretical Analysis

MedKoo Cat#: 591186

Name: ADL-08-0011

CAS#: 156130-41-5 (free base)

Chemical Formula: C23H29NO3

Exact Mass: 367.2147

Molecular Weight: 367.49

Elemental Analysis: C, 75.17; H, 7.95; N, 3.81; O, 13.06

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Related CAS #
156130-41-5 (free base) 170098-43-8 (HCl)
Synonym
ADL 08-0011; ADL-08-0011; ADL-08-0011
IUPAC/Chemical Name
1-Piperidinepropanoic acid, 4-(3-hydroxyphenyl)-3,4-dimethyl-alpha-(phenylmethyl)-, (alphaS,3R,4R)-
InChi Key
KSBSLJKYJXTATP-WCAVRKLYSA-N
InChi Code
InChI=1S/C23H29NO3/c1-17-15-24(12-11-23(17,2)20-9-6-10-21(25)14-20)16-19(22(26)27)13-18-7-4-3-5-8-18/h3-10,14,17,19,25H,11-13,15-16H2,1-2H3,(H,26,27)/t17-,19-,23+/m0/s1
SMILES Code
O=C(O)[C@@H](CC1=CC=CC=C1)CN2C[C@H](C)[C@](C)(C3=CC=CC(O)=C3)CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 367.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Armstrong SR, Campbell CB, Richardson CL, Vickery RG, Tsuruda PR, Long DD, Hegde SS, Beattie DT. The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):471-8. doi: 10.1007/s00210-013-0844-5. Epub 2013 Mar 13. PubMed PMID: 23512167. 2: Beattie DT, Cheruvu M, Mai N, O'Keefe M, Johnson-Rabidoux S, Peterson C, Kaufman E, Vickery R. The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone. Naunyn Schmiedebergs Arch Pharmacol. 2007 May;375(3):205-20. Epub 2007 Mar 6. PubMed PMID: 17340127.