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MedKoo Cat#: 413281 | Name: Prednisolone acetate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prednisolone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is the 21-acetate ester of prednisolone. This medication is used to treat certain eye conditions due to inflammation or injury.

Chemical Structure

Prednisolone acetate
CAS#52-21-1 (acetate)

Theoretical Analysis

MedKoo Cat#: 413281

Name: Prednisolone acetate

CAS#: 52-21-1 (acetate)

Chemical Formula: C23H30O6

Exact Mass: 402.2042

Molecular Weight: 402.49

Elemental Analysis: C, 68.64; H, 7.51; O, 23.85

Price and Availability

Size Price Availability Quantity
500mg USD 90.00 Ready to ship
1g USD 150.00 Ready to ship
2g USD 250.00 Ready to ship
5g USD 478.00 Ready to ship
10g USD 750.00 Ready to ship
25g USD 1,450.00 Ready to ship
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Related CAS #
52-21-1 (acetate) 72064-79-0 (valerate acetate) 630-67-1 (sodium metazoate) 125-02-0 (Na+ phosphate) 50-24-8 (free)
Synonym
Prednisolone acetate; Omnipred; Prednisolone 21-acetate; Econopred; NSC10966; NSC-10966; NSC 10966
IUPAC/Chemical Name
11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate
InChi Key
LRJOMUJRLNCICJ-JZYPGELDSA-N
InChi Code
InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h6,8,10,16-18,20,26,28H,4-5,7,9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
SMILES Code
C[C@@]12[C@](C(COC(C)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
Prednisolone acetate (Prednisolone 21-acetate) is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.
In vitro activity:
This study reports here a study of Prednisolone treatment using as a model a leukemia cell line with subsequent investigation of resistance-related gene expression. This study analyzed effects of increasing doses of Prednisolone on ALL cell survival and growth, and monitored immediate effects on gene expression through gene expression assays. Upon treatment with escalating Prednisolone concentration, this study observed a gradual decline in cell survival. Prednisolone competitively induces MCL1 expression. Reference: Adv Exp Med Biol. 2021;1339:147-160. https://pubmed.ncbi.nlm.nih.gov/35023102/
In vivo activity:
This study evaluated the effect of in vivo administration of prednisolone on Escherichia coli lipopolysaccharide endotoxin (LPS)-induced increases in plasma RNI and neutrophil mRNA for NOS II and production of RNI in the rat. This study shows that LPS rapidly induces mRNA for NOS II and production of RNI (NO2- and NO3- anion) in rat neutrophils within 2 hr after in vivo administration of a sublethal dose of 0.5 mg/kg, i.v. A pharmacologic dose of prednisolone (50 micrograms/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppressed LPS-stimulated mRNA for NOS II. 3-Amino, 1,2,4-triazine inhibited NO2- and NO3- production without affecting gene expression for NOS II. Reference: Proc Soc Exp Biol Med. 1994 Mar;205(3):220-9. https://pubmed.ncbi.nlm.nih.gov/7513433/
Solvent mg/mL mM comments
Solubility
DMSO 65.5 162.74
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 402.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. G L, Adamaki M, Hatziagapiou K, Geronikolou SA, Tsartsalis AN, Vlahopoulos S. Early and Very Early GRIM19 and MCL1 Expression Are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line. Adv Exp Med Biol. 2021;1339:147-160. doi: 10.1007/978-3-030-78787-5_20. PMID: 35023102. 2. Li C, Yang P, Liu B, Bu J, Liu H, Guo J, Hasegawa T, Si H, Li M. Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3β/β-catenin pathway. J Mol Histol. 2021 Oct;52(5):1081-1095. doi: 10.1007/s10735-021-10006-0. Epub 2021 Jul 23. PMID: 34297260. 3. Rioja I, Bush KA, Buckton JB, Dickson MC, Life PF. Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment. Clin Exp Immunol. 2004 Jul;137(1):65-73. doi: 10.1111/j.1365-2249.2004.02499.x. PMID: 15196245; PMCID: PMC1809073. 4. Kolls J, Xie J, LeBlanc R, Malinski T, Nelson S, Summer W, Greenberg SS. Rapid induction of messenger RNA for nitric oxide synthase II in rat neutrophils in vivo by endotoxin and its suppression by prednisolone. Proc Soc Exp Biol Med. 1994 Mar;205(3):220-9. doi: 10.3181/00379727-205-43700. PMID: 7513433.
In vitro protocol:
1. G L, Adamaki M, Hatziagapiou K, Geronikolou SA, Tsartsalis AN, Vlahopoulos S. Early and Very Early GRIM19 and MCL1 Expression Are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line. Adv Exp Med Biol. 2021;1339:147-160. doi: 10.1007/978-3-030-78787-5_20. PMID: 35023102. 2. Li C, Yang P, Liu B, Bu J, Liu H, Guo J, Hasegawa T, Si H, Li M. Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3β/β-catenin pathway. J Mol Histol. 2021 Oct;52(5):1081-1095. doi: 10.1007/s10735-021-10006-0. Epub 2021 Jul 23. PMID: 34297260.
In vivo protocol:
1. Rioja I, Bush KA, Buckton JB, Dickson MC, Life PF. Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment. Clin Exp Immunol. 2004 Jul;137(1):65-73. doi: 10.1111/j.1365-2249.2004.02499.x. PMID: 15196245; PMCID: PMC1809073. 2. Kolls J, Xie J, LeBlanc R, Malinski T, Nelson S, Summer W, Greenberg SS. Rapid induction of messenger RNA for nitric oxide synthase II in rat neutrophils in vivo by endotoxin and its suppression by prednisolone. Proc Soc Exp Biol Med. 1994 Mar;205(3):220-9. doi: 10.3181/00379727-205-43700. PMID: 7513433.
1: Saady AM, Fouad HM, Abdullatif AM, Helmy YAH, Macky TA, Mansour K. The value of prednisolone acetate provocative test before intravitreal triamcinolone acetonide injections. Eur J Ophthalmol. 2020 Jul;30(4):730-737. doi: 10.1177/1120672119842731. Epub 2019 Apr 12. PMID: 30977377. 2: KhalafAllah MT, Basiony A, Salama A. Difluprednate versus Prednisolone Acetate after Cataract Surgery: a Systematic Review and Meta-Analysis. BMJ Open. 2019 Nov 2;9(11):e026752. doi: 10.1136/bmjopen-2018-026752. PMID: 31678934; PMCID: PMC6830689. 3: Hanafy AF, Abdalla AM, Guda TK, Gabr KE, Royall PG, Alqurshi A. Ocular anti- inflammatory activity of prednisolone acetate loaded chitosan-deoxycholate self- assembled nanoparticles. Int J Nanomedicine. 2019 May 29;14:3679-3689. doi: 10.2147/IJN.S195892. PMID: 31239660; PMCID: PMC6556883. 4: Tijunelis MA, Person E, Niziol LM, Musch DC, Ernest P, McBain M, Mian SI. Comparison of prednisolone acetate 1.0% and difluprednate ophthalmic emulsion 0.05% after cataract surgery: Incidence of postoperative steroid-induced ocular hypertension. J Cataract Refract Surg. 2017 Feb;43(2):223-227. doi: 10.1016/j.jcrs.2017.02.002. PMID: 28366370. 5: Loukovaara S, Lehtinen V, Nieminen R, Moilanen J. Topical levofloxacin, nepafenac and prednisolone acetate medication after cataract surgery in the biggest tertiary eye hospital in Finland during 2015-2018. Acta Ophthalmol. 2019 Sep;97(6):e943-e945. doi: 10.1111/aos.14091. Epub 2019 Mar 27. PMID: 30916844. 6: Qiao J, Liu A, Liu J, Guan D, Chen T. Salvianolic acid B (Sal B) alleviates the decreased activity induced by prednisolone acetate on osteoblasts by up- regulation of bone formation and differentiation genes. Food Funct. 2019 Sep 1;10(9):6184-6192. doi: 10.1039/c9fo01246j. Epub 2019 Sep 10. PMID: 31501830. 7: Sheppard J, Garg S, Lievens C, Brandano L, Wirostko B, Korenfeld M, Raizman M, Foster CS. Iontophoretic Dexamethasone Phosphate Compared to Topical Prednisolone Acetate 1% for Noninfectious Anterior Segment Uveitis. Am J Ophthalmol. 2020 Mar;211:76-86. doi: 10.1016/j.ajo.2019.10.032. Epub 2019 Nov 11. PMID: 31726034. 8: Sheppard JD, Foster CS, Toyos MM, Markwardt K, Da Vanzo R, Flynn TE, Kempen JH. Difluprednate 0.05% versus Prednisolone Acetate 1% for Endogenous Anterior Uveitis: Pooled Efficacy Analysis of Two Phase 3 Studies. Ocul Immunol Inflamm. 2019;27(3):484-496. doi: 10.1080/09273948.2017.1407433. Epub 2017 Dec 20. PMID: 29260952. 9: Sousa FJ. The bioavailability and therapeutic effectiveness of prednisolone acetate vs. prednisolone sodium phosphate: a 20-year review. CLAO J. 1991 Oct;17(4):282-4. PMID: 1764775. 10: Rankin AJ, KuKanich KS, Schermerhorn T, Bello NM, Huey JA, Fentiman KE, Meekins JM. Evaluation of diabetes mellitus regulation in dogs treated with ophthalmic preparations of prednisolone acetate versus diclofenac sodium. Am J Vet Res. 2019 Dec;80(12):1129-1135. doi: 10.2460/ajvr.80.12.1129. PMID: 31763946.