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MedKoo Cat#: 592952 | Name: Chlorhexidine hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorhexidine hydrochloride is an Anti-Infective drug.

Chemical Structure

Chlorhexidine hydrochloride
Chlorhexidine hydrochloride
CAS#3697-42-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 592952

Name: Chlorhexidine hydrochloride

CAS#: 3697-42-5 (HCl)

Chemical Formula: C22H32Cl4N10

Exact Mass: 576.1566

Molecular Weight: 578.37

Elemental Analysis: C, 45.69; H, 5.58; Cl, 24.52; N, 24.22

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 650.00 2 Weeks
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Related CAS #
77146-42-0 (phosphanilate) 3697-42-5 (HCl) 18472-51-0 (gluconate) 55-56-1 (free base)
Synonym
Chlorhexidine hydrochloride; Chlorhexidine HCl; Chlorhexidine dihydrochloride; Chlorhexidine 2HCl; CHX
IUPAC/Chemical Name
2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, dihydrochloride
InChi Key
WJLVQTJZDCGNJN-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H30Cl2N10.2ClH/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;;/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H
SMILES Code
N=C(NC1=CC=C(Cl)C=C1)NC(NCCCCCCNC(NC(NC2=CC=C(Cl)C=C2)=N)=N)=N.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 578.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Trombelli L, Simonelli A, Pramstraller M, Guarnelli ME, Fabbri C, Maietti E, Farina R. Clinical efficacy of a chlorhexidine-based mouthrinse containing hyaluronic acid and an antidiscoloration system in patients undergoing flap surgery: A triple-blind, parallel-arm, randomized controlled trial. Int J Dent Hyg. 2018 Aug 12. doi: 10.1111/idh.12361. [Epub ahead of print] PubMed PMID: 30101416. 2: da Silveira PV, Panariello BHD, de Araújo Costa CAG, Maule SM, Maule SM, Janal MN, Zanin ICJ, Duarte S. Twice-daily red and blue light treatment for Candida albicans biofilm matrix development control. Lasers Med Sci. 2018 Aug 10. doi: 10.1007/s10103-018-2610-x. [Epub ahead of print] PubMed PMID: 30097756. 3: Buchele MLC, Wopereis DB, Casara F, de Macedo JP, Rott MB, Monteiro FBF, Bazzo ML, Dos Reis Spada F, Dos Santos JI, Caumo KS. Contact lens-related polymicrobial keratitis: Acanthamoeba spp. genotype T4 and Candida albicans. Parasitol Res. 2018 Aug 10. doi: 10.1007/s00436-018-6037-x. [Epub ahead of print] PubMed PMID: 30094541. 4: Patni PM, Jain P, Hiremath H, Raghuwanshi S, Vijaywargia P, Patni MJ. Cutaneous dental sinus of submental region: an eight years follow-up. Clujul Med. 2018 Jul;91(3):351-356. doi: 10.15386/cjmed-812. Epub 2018 Jul 31. PubMed PMID: 30093817; PubMed Central PMCID: PMC6082611. 5: Khoshnevisan K, Maleki H, Samadian H, Shahsavari S, Sarrafzadeh MH, Larijani B, Dorkoosh FA, Haghpanah V, Khorramizadeh MR. Cellulose acetate electrospun nanofibers for drug delivery systems: Applications and recent advances. Carbohydr Polym. 2018 Oct 15;198:131-141. doi: 10.1016/j.carbpol.2018.06.072. Epub 2018 Jun 18. Review. PubMed PMID: 30092983. 6: Ghabraei S, Bolhari B, Sabbagh MM, Afshar MS. Comparison of Antimicrobial Effects of Triple Antibiotic Paste and Calcium Hydroxide Mixed with 2% Chlorhexidine as Intracanal Medicaments Against Enterococcus faecalis Biofilm. J Dent (Tehran). 2018 May;15(3):151-160. PubMed PMID: 30090115; PubMed Central PMCID: PMC6079187. 7: Lantigua Domínguez MC, Feliz Pedrinha V, Oliveira Athaide da Silva LC, Soares Ribeiro ME, Loretto SC, de Almeida Rodrigues P. Effects of Different Irrigation Solutions on Root Fracture Resistance: An in Vitro Study. Iran Endod J. 2018 Summer;13(3):367-372. doi: 10.22037/iej.v13i3.19247. PubMed PMID: 30083208; PubMed Central PMCID: PMC6064013. 8: Samiei M, Torab A, Hosseini O, Abbasi T, Abdollahi AA, Divband B. Antibacterial Effect of Two Nano Zinc Oxide Gel Preparations Compared to Calcium Hydroxide and Chlorhexidine Mixture. Iran Endod J. 2018 Summer;13(3):305-311. doi: 10.22037/iej.v13i3.19866. PubMed PMID: 30083198; PubMed Central PMCID: PMC6064019. 9: Nabavizadeh M, Ghahramani Y, Abbaszadegan A, Jamshidzadeh A, Jenabi P, Makarempour A. In Vivo Biocompatibility of an Ionic Liquid-protected Silver Nanoparticle Solution as Root Canal Irrigant. Iran Endod J. 2018 Summer;13(3):293-298. doi: 10.22037/iej.v13i3.17386. PubMed PMID: 30083196; PubMed Central PMCID: PMC6064014. 10: Melok AL, Lee LH, Mohamed Yussof SA, Chu T. Green Tea Polyphenol Epigallocatechin-3-Gallate-Stearate Inhibits the Growth of Streptococcus mutans: A Promising New Approach in Caries Prevention. Dent J (Basel). 2018 Aug 6;6(3). pii: E38. doi: 10.3390/dj6030038. PubMed PMID: 30082585. 11: Cvikl B, Lussi A, Carvalho TS, Moritz A, Gruber R. Stannous chloride and stannous fluoride are inhibitors of matrix metalloproteinases. J Dent. 2018 Aug 3. pii: S0300-5712(18)30242-2. doi: 10.1016/j.jdent.2018.08.002. [Epub ahead of print] PubMed PMID: 30081053. 12: Barkhuff D, Nitta CH, Cobb R, Ernst AA, Weiss SJ. Bathing Habits in Emergency Department Patients with Cellulitis or Abscess Versus Controls. South Med J. 2018 Aug;111(8):489-493. doi: 10.14423/SMJ.0000000000000849. PubMed PMID: 30075475. 13: Gupta A, Nair RR, Moorthy RK, Rajshekhar V. Impact of staphylococcal decolonization regime and change in antibiotic prophylaxis regime on incidence of post-craniotomy aseptic meningitis. World Neurosurg. 2018 Jul 31. pii: S1878-8750(18)31680-2. doi: 10.1016/j.wneu.2018.07.200. [Epub ahead of print] PubMed PMID: 30075267. 14: Sadeghi H, Alizadehdiz A, Fazelifar A, Emkanjoo Z, Haghjoo M. New Insights into Predictors of Cardiac Implantable Electronic Device Infection. Tex Heart Inst J. 2018 Jun 1;45(3):128-135. doi: 10.14503/THIJ-17-6300. eCollection 2018 Jun. PubMed PMID: 30072848; PubMed Central PMCID: PMC6059506. 15: Niyyati M, Sasani R, Mohebali M, Ghazikhansari M, Kargar F, Hajialilo E, Rezaeian M. Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions. Iran J Parasitol. 2018 Apr-Jun;13(2):180-185. PubMed PMID: 30069201; PubMed Central PMCID: PMC6068380. 16: Singh J, Joshi A, Manjooran T, Raghav S, Gautam A, Patel JH. An in vitro Evaluation of Shear Bond Strength of Orthodontic Brackets after Mouth Rinse. J Contemp Dent Pract. 2018 Jul 1;19(7):862-866. PubMed PMID: 30066692. 17: Vamsi K, Siddiqui F. Antimicrobial Effect of an Experimental Glass lonomer Cement against Pathogens associated with Deep Carious Lesions. J Contemp Dent Pract. 2018 Jul 1;19(7):824-829. PubMed PMID: 30066686. 18: Deschepper M, Vogelaers D, Blot S. Chlorhexidine-related ventilator-associated events: Toward recognition? Infect Control Hosp Epidemiol. 2018 Aug 1:1-2. doi: 10.1017/ice.2018.173. [Epub ahead of print] PubMed PMID: 30064537. 19: Khaky B, Yazdannik A, Mahjobipoor H. Evaluating the Efficacy of Nanosil Mouthwash on the Preventing Pulmonary Infection in Intensive Care Unit: a Randomized Clinical Trial. Med Arch. 2018 Jun;72(3):206-209. doi: 10.5455/medarh.2018.72.206-209. PubMed PMID: 30061768; PubMed Central PMCID: PMC6021149. 20: Bolton L. Chlorhexidine Patient Bathing Prior to Arthroplasty. Wounds. 2018 Jul;30(7):213-215. PubMed PMID: 30059339.