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MedKoo Cat#: 412849 | Name: Chlorhexidine phosphanilate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorhexidine phosphanilate is an antibacterial used for prophylactic treatment of burns.

Chemical Structure

Chlorhexidine phosphanilate
Chlorhexidine phosphanilate
CAS#77146-42-0 (phosphanilate)

Theoretical Analysis

MedKoo Cat#: 412849

Name: Chlorhexidine phosphanilate

CAS#: 77146-42-0 (phosphanilate)

Chemical Formula: C34H46Cl2N12O6P2

Exact Mass: 850.2516

Molecular Weight: 851.67

Elemental Analysis: C, 47.95; H, 5.44; Cl, 8.32; N, 19.74; O, 11.27; P, 7.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
77146-42-0 (phosphanilate) 3697-42-5 (HCl) 18472-51-0 (gluconate) 55-56-1 (free base)
Synonym
Chlorhexidine phosphanilate; WP973; WP-973; WP 973
IUPAC/Chemical Name
2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, (4-aminophenyl)phosphonate (1:2)
InChi Key
NSCOCGOFKMUTMW-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H30Cl2N10.2C6H8NO3P/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-5-1-3-6(4-2-5)11(8,9)10/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1-4H,7H2,(H2,8,9,10)
SMILES Code
N=C(NC1=CC=C(Cl)C=C1)NC(NCCCCCCNC(NC(NC2=CC=C(Cl)C=C2)=N)=N)=N.NC3=CC=C(P(O)(O)=O)C=C3.NC4=CC=C(P(O)(O)=O)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 851.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang JC, Williams RR, Wang L, Loder J. In vitro skin permeation and bioassay of chlorhexidine phosphanilate, a new antimicrobial agent. Pharm Res. 1990 Oct;7(10):995-1002. doi: 10.1023/a:1015978714186. PMID: 2281046. 2: Miller LM, Loder JS, Hansbrough JF, Peterson HD, Monafo WW, Jordan MH. Patient tolerance study of topical chlorhexidine diphosphanilate: a new topical agent for burns. Burns. 1990 Jun;16(3):217-20. doi: 10.1016/0305-4179(90)90044-w. PMID: 2383364. 3: Loder JS, Krochmal L. Topical chlorhexidine phosphanilate for prophylactic treatment of burns. N Engl J Med. 1986 May 8;314(19):1256-7. PMID: 3702924. 4: Gadde RR, McNiff EF, Peer MM. High-performance liquid chromatographic analysis of chlorhexidine phosphanilate, a new antimicrobial agent. J Pharm Biomed Anal. 1991;9(10-12):1031-6. doi: 10.1016/0731-7085(91)80040-g. PMID: 1822169.