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MedKoo Cat#: 317505 | Name: Chlorhexidine Gluconate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorhexidine digluconate solution is a bis-biguanide family cationic broad spectrum antibiotic. Studies indicate that chlorhexidine digluconate solution functions, via destabilization of the outer bacterial membrane, which resulted in the release of periplasmic enzymes in gram negative bacteria. In addition, Chlorhexidine digluconate solution inhibits oxygen utilization which leads to a reduction in bacterial ATP. Furthermore, Chlorhexidine digluconate solution is very effective against bacteria such as Propionibacterium, Selenomonas, and cocci resembling Veillonella. Note: This product is being supplied as 20% (~200mg/mL) aqueous solution, non-sterile.

Chemical Structure

Chlorhexidine Gluconate
Chlorhexidine Gluconate
CAS#18472-51-0 (gluconate)

Theoretical Analysis

MedKoo Cat#: 317505

Name: Chlorhexidine Gluconate

CAS#: 18472-51-0 (gluconate)

Chemical Formula: C34H54Cl2N10O14

Exact Mass: 0.0000

Molecular Weight: 897.76

Elemental Analysis: C, 45.49; H, 6.06; Cl, 7.90; N, 15.60; O, 24.95

Price and Availability

Size Price Availability Quantity
25g USD 250.00 2 Weeks
100g USD 550.00 2 Weeks
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Related CAS #
77146-42-0 (phosphanilate) 3697-42-5 (HCl) 18472-51-0 (gluconate) 55-56-1 (free base)
Synonym
Chlorhexidine Gluconate; Chlorhexidine digluconate; Unisept; Peridex; 18472-51-0; UNII-MOR84MUD8E; Gibitan; Hexidine; Hibiclens; Hibident; Hibiscrub; Hibisol; Hibitane; Peridex; Perio Chip;
IUPAC/Chemical Name
1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] Digluconate
InChi Key
YZIYKJHYYHPJIB-UUPCJSQJSA-N
InChi Code
InChI=1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1
SMILES Code
N=C(NC(NC1=CC=C(Cl)C=C1)=N)NCCCCCCNC(NC(NC2=CC=C(Cl)C=C2)=N)=N.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C(O)=O.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C(O)=O
Appearance
clear solution.
Purity
20% w/v aq. soln., non-sterile
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 897.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bibi S, Shah SA, Qureshi S, Siddiqui TR, Soomro IA, Ahmed W, Alam SE. Is chlorhexidine-gluconate superior than Povidone-Iodine in preventing surgical site infections? A multicenter study. J Pak Med Assoc. 2015 Nov;65(11):1197-201. PubMed PMID: 26564292. 2: Edmiston CE Jr, Lee CJ, Krepel CJ, Spencer M, Leaper D, Brown KR, Lewis BD, Rossi PJ, Malinowski MJ, Seabrook GR. Evidence for a Standardized Preadmission Showering Regimen to Achieve Maximal Antiseptic Skin Surface Concentrations of Chlorhexidine Gluconate, 4%, in Surgical Patients. JAMA Surg. 2015 Nov 1;150(11):1027-33. doi: 10.1001/jamasurg.2015.2210. PubMed PMID: 26308490. 3: Srinivas A, Kaman L, Raj P, Gautam V, Dahiya D, Singh G, Singh R, Medhi B. Comparison of the efficacy of chlorhexidine gluconate versus povidone iodine as preoperative skin preparation for the prevention of surgical site infections in clean-contaminated upper abdominal surgeries. Surg Today. 2015 Nov;45(11):1378-84. doi: 10.1007/s00595-014-1078-y. Epub 2014 Nov 9. PubMed PMID: 25381486. 4: Aqeel Y, Siddiqui R, Anwar A, Shah MR, Khan NA. Gold nanoparticle conjugation enhanced anti-Acanthamoebic effects of chlorhexidine gluconate. Antimicrob Agents Chemother. 2015 Dec 14. pii: AAC.01123-15. [Epub ahead of print] PubMed PMID: 26666949. 5: Shah HN, Schwartz JL, Luna G, Cullen DL. Bathing With 2% Chlorhexidine Gluconate: Evidence and Costs Associated With Central Line-Associated Bloodstream Infections. Crit Care Nurs Q. 2016 Jan-Mar;39(1):42-50. doi: 10.1097/CNQ.0000000000000096. PubMed PMID: 26633158. 6: Alawadi ZM, Kao LS. Chlorhexidine Gluconate, 4%, Showers and Surgical Site Infection Reduction. JAMA Surg. 2015 Nov 1;150(11):1033. doi: 10.1001/jamasurg.2015.2219. PubMed PMID: 26308068. 7: Smith DC, Maiman R, Schwechter EM, Kim SJ, Hirsh DM. Optimal Irrigation and Debridement of Infected Total Joint Implants with Chlorhexidine Gluconate. J Arthroplasty. 2015 Oct;30(10):1820-2. doi: 10.1016/j.arth.2015.05.005. Epub 2015 May 15. PubMed PMID: 26105616. 8: Goel A, Sinha A, Khandeparker RV, Mehrotra R, Vashisth P, Garg A. Bioactive Glass S53P4 versus Chlorhexidine Gluconate as Intracanal Medicament in Primary Teeth: An In-vivo Study Using Polymerase Chain Reaction Analysis. J Int Oral Health. 2015 Aug;7(8):65-9. PubMed PMID: 26464542; PubMed Central PMCID: PMC4588793. 9: Casey A, Itrakjy A, Birkett C, Clethro A, Bonser R, Graham T, Mascaro J, Pagano D, Rooney S, Wilson I, Nightingale P, Crosby C, Elliott T. A comparison of the efficacy of 70% v/v isopropyl alcohol with either 0.5% w/v or 2% w/v chlorhexidine gluconate for skin preparation before harvest of the long saphenous vein used in coronary artery bypass grafting. Am J Infect Control. 2015 Aug;43(8):816-20. doi: 10.1016/j.ajic.2015.03.034. Epub 2015 May 13. PubMed PMID: 25979197. 10: Dalgleish L, Jhattu H, Gomersall JS. Daily 2% chlorhexidine gluconate bath wash in a tertiary adult intensive care and high dependency units to reduce risk of hospital acquired multi resistant organisms: a best practice implementation project. JBI Database System Rev Implement Rep. 2015 Jul 17;13(6):434-48. doi: 10.11124/jbisrir-2015-2206. PubMed PMID: 26455757. 11: Yadav NS, Saraf S, Mishra SK, Hazari P. Effects of fluconazole, chlorhexidine gluconate, and silver-zinc zeolite on flexural strength of heat-cured polymethyl methacrylate resin. J Nat Sci Biol Med. 2015 Jul-Dec;6(2):340-2. doi: 10.4103/0976-9668.159999. PubMed PMID: 26283825; PubMed Central PMCID: PMC4518405. 12: Davids BI, Davidson MJ, TenBroeck SH, Colahan PT, Oli MW. Efficacy of Mechanical versus Non-Mechanical Sterile Preoperative Skin Preparation With Chlorhexidine Gluconate 4% Solution. Vet Surg. 2015 Jul;44(5):648-52. doi: 10.1111/vsu.12335. Epub 2015 Apr 24. PubMed PMID: 25913145. 13: Prasad KA, John S, Deepika V, Dwijendra KS, Reddy BR, Chincholi S. Anti-Plaque Efficacy of Herbal and 0.2% Chlorhexidine Gluconate Mouthwash: A Comparative Study. J Int Oral Health. 2015 Aug;7(8):98-102. PubMed PMID: 26464549; PubMed Central PMCID: PMC4588801. 14: Kim JM, Ahn Y, LiPuma JJ, Hussong D, Cerniglia CE. Survival and susceptibility of Burkholderia cepacia complex in chlorhexidine gluconate and benzalkonium chloride. J Ind Microbiol Biotechnol. 2015 Jun;42(6):905-13. doi: 10.1007/s10295-015-1605-x. Epub 2015 Mar 21. PubMed PMID: 25794566. 15: Gupta D, Jain A. Effect of Cinnamon Extract and Chlorhexidine Gluconate (0.2%) on the Clinical Level of Dental Plaque and Gingival Health: A 4-Week, Triple-Blind Randomized Controlled Trial. J Int Acad Periodontol. 2015 Jul;17(3):91-8. PubMed PMID: 26373226. 16: Edmiston CE Jr, Assadian O, Spencer M, Olmsted RN, Barnes S, Leaper D. To bathe or not to bathe with chlorhexidine gluconate: is it time to take a stand for preadmission bathing and cleansing? AORN J. 2015 May;101(5):529-38. doi: 10.1016/j.aorn.2015.02.008. PubMed PMID: 25946179. 17: Chen W, Cao Q, Li S, Li H, Zhang W. Impact of daily bathing with chlorhexidine gluconate on ventilator associated pneumonia in intensive care units: a meta-analysis. J Thorac Dis. 2015 Apr;7(4):746-53. doi: 10.3978/j.issn.2072-1439.2015.04.21. PubMed PMID: 25973242; PubMed Central PMCID: PMC4419331. 18: Hambire CU, Jawade R, Patil A, Wani VR, Kulkarni AA, Nehete PB. Comparing the antiplaque efficacy of 0.5% Camellia sinensis extract, 0.05% sodium fluoride, and 0.2% chlorhexidine gluconate mouthwash in children. J Int Soc Prev Community Dent. 2015 May-Jun;5(3):218-26. doi: 10.4103/2231-0762.158016. PubMed PMID: 26236682; PubMed Central PMCID: PMC4515805. 19: Shams WE, Hanley GA, Orvik A, Lewis N, Shurbaji MS. Peritoneal lavage using chlorhexidine gluconate at the end of colon surgery reduces postoperative intra-abdominal infection in mice. J Surg Res. 2015 May 1;195(1):121-7. doi: 10.1016/j.jss.2015.01.030. Epub 2015 Jan 22. PubMed PMID: 25687961. 20: Jones R, Hutton A, Mariyaselvam M, Hodges E, Wong K, Blunt M, Young P. Keyboard cleanliness: a controlled study of the residual effect of chlorhexidine gluconate. Am J Infect Control. 2015 Mar 1;43(3):289-91. doi: 10.1016/j.ajic.2014.12.002. PubMed PMID: 25728156.