Synonym
Mimopezil; Debio-9902; Debio-9902-SR; ZT-1; DEBIO-9902; ZT-1 LA.
IUPAC/Chemical Name
(5R,9R,E)-5-(((E)-5-chloro-2-hydroxy-3-methoxybenzylidene)amino)-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
InChi Key
UYRWZANUXPUEPQ-ALWBHENDSA-N
InChi Code
InChI=1S/C23H23ClN2O3/c1-4-17-14-7-13(2)11-23(17,18-5-6-21(27)26-19(18)9-14)25-12-15-8-16(24)10-20(29-3)22(15)28/h4-8,10,12,14,28H,9,11H2,1-3H3,(H,26,27)/b17-4+,25-12+/t14-,23+/m0/s1
SMILES Code
O=C1C=CC([C@@](/C2=C/C)(/N=C/C3=CC(Cl)=CC(OC)=C3O)CC(C)=C[C@@]2([H])C4)=C4N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
410.90
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jia JY, Zhao QH, Liu Y, Gui YZ, Liu GY, Zhu DY, Yu C, Hong Z. Phase I study on
the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the
treatment of Alzheimer's disease. Acta Pharmacol Sin. 2013 Jul;34(7):976-82. doi:
10.1038/aps.2013.7. PubMed PMID: 23624756; PubMed Central PMCID: PMC4002618.
2: Wei G, Xiao S, Lu R, Liu C. Simultaneous determination of ZT-1 and its
metabolite Huperzine A in plasma by high-performance liquid chromatography with
ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan
2;830(1):120-5. PubMed PMID: 16288904.
3: Li C, Du F, Yu C, Xu X, Zheng J, Xu F, Zhu D. A sensitive method for the
determination of the novel cholinesterase inhibitor ZT-1 and its active
metabolite huperzine A in rat blood using liquid chromatography/tandem mass
spectrometry. Rapid Commun Mass Spectrom. 2004;18(6):651-6. PubMed PMID:
15052575.
