MedKoo Cat#: 592815 | Name: Amlodipine besylate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amlodipine besylate is an Anti-Anginal drug.

Chemical Structure

Amlodipine besylate
Amlodipine besylate
CAS#111470-99-6 (besylate)

Theoretical Analysis

MedKoo Cat#: 592815

Name: Amlodipine besylate

CAS#: 111470-99-6 (besylate)

Chemical Formula: C26H31ClN2O8S

Exact Mass: 566.1490

Molecular Weight: 567.05

Elemental Analysis: C, 55.07; H, 5.51; Cl, 6.25; N, 4.94; O, 22.57; S, 5.65

Price and Availability

Size Price Availability Quantity
2g USD 250.00 2 Weeks
5g USD 450.00 2 Weeks
10g USD 650.00 2 Weeks
25g USD 1,250.00 2 Weeks
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Synonym
Amlodipine besylate; Cardiorex; Cordarene
IUPAC/Chemical Name
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate
InChi Key
ZPBWCRDSRKPIDG-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
SMILES Code
O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC.O=S(C3=CC=CC=C3)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 567.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sievers P, Uhlmann L, Korkmaz-Icöz S, Fastner C, Bea F, Blessing E, Katus HA, Preusch MR. Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis. Drug Des Devel Ther. 2015 Jul 29;9:3935-42. doi: 10.2147/DDDT.S85203. eCollection 2015. PubMed PMID: 26251572; PubMed Central PMCID: PMC4524379. 2: Nam JH, Oh M, Kim HJ, Han SK, Kim EJ, Song GS, Kim EY, Shin JG, Ghim JL, Kim HS. Pharmacokinetic comparison of amlodipine adipate/valsartan fixed-dose combination with amlodipine besylate/valsartan fixed-dose combination in healthy volunteers. Int J Clin Pharmacol Ther. 2015 Jan;53(1):66-74. doi: 10.5414/CP202045. PubMed PMID: 25034618. 3: Lee SY, Kim JR, Jung JA, Huh W, Bahng MY, Ko JW. Bioequivalence evaluation of two amlodipine salts, besylate and orotate, each in a fixed-dose combination with olmesartan in healthy subjects. Drug Des Devel Ther. 2015 Jun 2;9:2811-7. doi: 10.2147/DDDT.S82820. eCollection 2015. PubMed PMID: 26082611; PubMed Central PMCID: PMC4459635. 4: Kaur M, Ita KB, Popova IE, Parikh SJ, Bair DA. Microneedle-assisted delivery of verapamil hydrochloride and amlodipine besylate. Eur J Pharm Biopharm. 2014 Feb;86(2):284-91. doi: 10.1016/j.ejpb.2013.10.007. Epub 2013 Oct 28. PubMed PMID: 24176676. 5: Vojta J, Jedlička A, Coufal P, Janečková L. A new, rapid, stability-indicating UPLC method for separation and determination of impurities in amlodipine besylate, valsartan and hydrochlorothiazide in their combined tablet dosage form. J Pharm Biomed Anal. 2015 May 10;109:36-44. doi: 10.1016/j.jpba.2015.01.059. Epub 2015 Feb 18. PubMed PMID: 25756663. 6: Shirley M, McCormack PL. Perindopril/amlodipine (Prestalia(®)): a review in hypertension. Am J Cardiovasc Drugs. 2015 Oct;15(5):363-70. doi: 10.1007/s40256-015-0144-1. Review. PubMed PMID: 26341621. 7: Jia T, Zhang LJ, Zhan YQ, Yu JM, Hu DY. [The effectiveness and safety of L-amlodipine besylate for blood pressure control in patients with mild to moderate essential hypertension]. Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Apr;41(4):301-3. Chinese. PubMed PMID: 23906400. 8: Hadžidedić S, Uzunović A, Sehić Jazić S, Kocova El-Arini S. The impact of chirality on the development of robust and stable tablet formulation of (S-) amlodipine besylate. Pharm Dev Technol. 2014 Dec;19(8):930-41. doi: 10.3109/10837450.2013.840847. Epub 2013 Oct 7. PubMed PMID: 24099553. 9: Kim KH, Kim WS. Chronic unilateral chemosis following the use of amlodipine besylate. BMC Ophthalmol. 2014 Oct 21;14:124. doi: 10.1186/1471-2415-14-124. PubMed PMID: 25335530; PubMed Central PMCID: PMC4216336. 10: Salim MM, Ebeid WM, El-Enany N, Belal F, Walash M, Patonay G. Simultaneous determination of aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide in their triple mixture dosage form by capillary zone electrophoresis. J Sep Sci. 2014 May;37(9-10):1206-13. doi: 10.1002/jssc.201301140. Epub 2014 Mar 25. PubMed PMID: 24574149. 11: Choi NY, Choi H, Park HH, Lee EH, Yu HJ, Lee KY, Joo Lee Y, Koh SH. Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells. Brain Res. 2014 Mar 10;1551:1-12. doi: 10.1016/j.brainres.2014.01.016. Epub 2014 Jan 16. PubMed PMID: 24440775. 12: Sharma M, Kothari C, Sherikar O, Mehta P. Concurrent estimation of amlodipine besylate, hydrochlorothiazide and valsartan by RP-HPLC, HPTLC and UV-spectrophotometry. J Chromatogr Sci. 2014 Jan;52(1):27-35. doi: 10.1093/chromsci/bms200. Epub 2013 Jan 4. PubMed PMID: 23293040. 13: Rapolu R, Raju ChK, Srinivas K, Awasthi A, Navalgund SG, Surendranath KV. Isolation and characterization of a novel acid degradation impurity of Amlodipine Besylate using Q-TOF, NMR, IR and single crystal X-ray. J Pharm Biomed Anal. 2014 Oct;99:59-66. doi: 10.1016/j.jpba.2014.07.006. Epub 2014 Jul 15. PubMed PMID: 25072842. 14: Ananchenko G, Novakovic J, Lewis J. Amlodipine besylate. Profiles Drug Subst Excip Relat Methodol. 2012;37:31-77. doi: 10.1016/B978-0-12-397220-0.00002-7. Epub 2012 Mar 19. Review. PubMed PMID: 22469316. 15: Ebeid WM, Elkady EF, El-Zaher AA, El-Bagary RI, Patonay G. Steady-state and synchronous spectrofluorimetric methods for simultaneous determination of aliskiren hemifumarate and amlodipine besylate in dosage forms. Luminescence. 2014 Nov;29(7):878-83. doi: 10.1002/bio.2636. Epub 2014 Mar 31. PubMed PMID: 24687516. 16: Elliott WJ. Rationale for a single-pill combination of perindopril arginine and amlodipine besylate. J Am Soc Hypertens. 2015 Apr;9(4):257-65. doi: 10.1016/j.jash.2014.12.012. Epub 2015 Jan 12. Review. PubMed PMID: 25817217. 17: Rakugi H, Nakata E, Sasaki E, Kagawa T. Evaluation of the efficacy and tolerability of fixed-dose combination therapy of azilsartan and amlodipine besylate in Japanese patients with grade I to II essential hypertension. Clin Ther. 2014 May;36(5):711-21. doi: 10.1016/j.clinthera.2014.03.009. Epub 2014 Apr 16. PubMed PMID: 24742498. 18: Jepson RE, Syme HM, Elliott J. Plasma renin activity and aldosterone concentrations in hypertensive cats with and without azotemia and in response to treatment with amlodipine besylate. J Vet Intern Med. 2014 Jan-Feb;28(1):144-53. doi: 10.1111/jvim.12240. Epub 2013 Nov 13. PubMed PMID: 24428319; PubMed Central PMCID: PMC4895535. 19: Özdemir FA, Akyüz A. Simultaneous determination of amlodipine and aliskren in tablets by high-performance liquid chromatography. J Chromatogr Sci. 2014 Aug;52(7):685-90. doi: 10.1093/chromsci/bmt099. Epub 2013 Jul 9. PubMed PMID: 23839804. 20: Belal TS, Mahrous MS, Abdel-Khalek MM, Daabees HG, Khamis MM. Validated spectrofluorimetric determination of two pharmaceutical antihypertensive mixtures containing amlodipine besylate together with either candesartan cilexetil or telmisartan. Luminescence. 2014 Nov;29(7):893-900. doi: 10.1002/bio.2638. Epub 2014 Feb 26. PubMed PMID: 24615878.