VU0463271 is a potent and selective inhibitor of the neuronal potassium-chloride cotransporter 2 (KCC2), exhibiting an IC₅₀ of 61 nM and demonstrating over 100-fold selectivity compared to the closely related Na-K-2Cl cotransporter 1 (NKCC1).
MedKoo Cat#: 592092
Name: VU0463271
CAS#: 1391737-01-1
Chemical Formula: C19H18N4OS2
Exact Mass: 382.0922
Molecular Weight: 382.50
Elemental Analysis: C, 59.66; H, 4.74; N, 14.65; O, 4.18; S, 16.76
The following data is based on the product molecular weight 382.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
