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MedKoo Cat#: 598765 | Name: Etafenone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Etafenone is a vasodilator used in therapy of anigna pectoris.

Chemical Structure

Etafenone
Etafenone
CAS#90-54-0

Theoretical Analysis

MedKoo Cat#: 598765

Name: Etafenone

CAS#: 90-54-0

Chemical Formula: C21H27NO2

Exact Mass: 325.2042

Molecular Weight: 325.45

Elemental Analysis: C, 77.50; H, 8.36; N, 4.30; O, 9.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2192-21-4 (HCl) 90-54-0 (free base)
Synonym
Etafenone; LG 11457; LG-11457; LG11457; Etafenonum;
IUPAC/Chemical Name
1-(2-(2-(diethylamino)ethoxy)phenyl)-3-phenylpropan-1-one
InChi Key
OEGDFSLNGABBKJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H27NO2/c1-3-22(4-2)16-17-24-21-13-9-8-12-19(21)20(23)15-14-18-10-6-5-7-11-18/h5-13H,3-4,14-17H2,1-2H3
SMILES Code
O=C(C1=CC=CC=C1OCCN(CC)CC)CCC2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 325.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ujiie A, Komatsu H, Kubota T, Hamano S, Naito J. [Studies on the inhibitory effect of etafenone hydrochloride on platelet aggregation]. Nihon Yakurigaku Zasshi. 1983 Jun;81(6):493-8. Japanese. PubMed PMID: 6618341. 2: Kitamura S, Ishihara Y. Effect of calcium antagonist, etafenone hydrochloride, on the isolated guinea pig tracheal tissues. Arzneimittelforschung. 1980;30(7):1088-91. PubMed PMID: 7191291. 3: Etoh Y, Nakazawa M, Imai S. Effects of etafenone on myocardial energy metabolism as studied by an organ redoximeter and biochemical analyses. Jpn J Pharmacol. 1984 Jul;35(3):229-35. PubMed PMID: 6482088. 4: Kukovetz WR. Modification of the cardiostimulatory and coronary dilator effect of isopreenaline caused by etafenone. Arzneimittelforschung. 1975 Jan;25(1):31-8. German. PubMed PMID: 238542. 5: Flohr H, Breull W. Effect of etafenone on total and regional myocardial blood flow. Arzneimittelforschung. 1975 Sep;25(9):1400-3. PubMed PMID: 23. 6: Toda H, Watanabe Y. Cardiac electrophysiologic effects of etafenone hydrochloride (Dialicor), a new antiarrhythmic agent. J Electrocardiol. 1979 Jul;12(3):283-93. PubMed PMID: 469443. 7: Diculescu I, Popescu LM. The effect of etafenone on the subcellular distribution of calcium and some oligoelements in heart muscle. Ultracytochemical and x-ray microanalytical study. Arzneimittelforschung. 1976;26(12):2158-64. PubMed PMID: 1037264. 8: Hashimoto K, Satoh H, Imai S. Effects of etafenone and antiarrhythmic drugs on Na and Ca channels of guinea pig atrial muscle. J Cardiovasc Pharmacol. 1979 Sep-Oct;1(5):561-70. PubMed PMID: 94412. 9: Hapke HJ, Sterner W. [Pharmacological and toxicological studies on the effect characterization of etafenone]. Arzneimittelforschung. 1969 Oct;19(10):1664-72. German. PubMed PMID: 5395365. 10: Raberger G, Weissel M. The effects of etafenone on the coronary and femoral circulations before and after adrenergic -blockade in intact dogs. Pharmacology. 1972;7(4):264-70. PubMed PMID: 4403998. 11: Kohlhardt M. [Inhibition of the slow-response action potential of mammalian ventricular myocardium by etafenone (author's transl)]. Arzneimittelforschung. 1979;29(2):218-21. German. PubMed PMID: 582134. 12: Ishihara Y, Inada E, Kitamura S. [Effect of calcium antagonist, etafenone hydrochloride, on the contractile responses in rabbit pulmonary artery and descending aorta strips (author's transl)]. Kokyu To Junkan. 1979 Nov;27(11):1203-7. Japanese. PubMed PMID: 523840. 13: Matsuo H, Matsui A, Nasu R, Takanaga H, Inoue N, Hattori F, Ohtani H, Sawada Y. Propiverine-induced Parkinsonism: a case report and a pharmacokinetic/pharmacodynamic study in mice. Pharm Res. 2000 May;17(5):565-71. PubMed PMID: 10888308. 14: Ishihara Y, Yotsumoto H, Kudoh S, Sasaki K, Kitamura S. [Effect of calcium antagonist (etafenone hydrochloride) on the isolated guinea pig tracheal tissues (author's transl)]. Kokyu To Junkan. 1978 Aug;26(8):767-71. Japanese. PubMed PMID: 694241. 15: Kukovetz WR. [Effect of ortho-(beta-diethylaminoethoxy)phenylpropiophenone x HCl (etafenone) on the dynamics, metabolism, O2-utilization and coronary flow of Heart]. Arzneimittelforschung. 1969 Oct;19(10):1672-7. German. PubMed PMID: 4391205. 16: Fierro B, Castiglione MG, Salemi G, Savettieri G. Myasthenia-like syndrome induced by cardiovascular agents. Report of a case. Ital J Neurol Sci. 1987 Apr;8(2):167-9. PubMed PMID: 3036745. 17: Sergeev PV, Dukhanin AS, Nikolaevskiĭ VA, Reznikov KM. [Effects of etafon on calcium ion contents in smooth muscle cells of the aorta]. Biull Eksp Biol Med. 1991 Aug;112(8):146-8. Russian. PubMed PMID: 1786372. 18: Hopf R, Becker HJ, Kober G, Dowinsky S, Kaltenbach M. [Treatment of angina pectoris with calcium antagonists]. Herz. 1982 Aug;7(4):221-34. Review. German. PubMed PMID: 6751971. 19: BROTZU G, BINAGHI G. [HEMODYNAMIC RESEARCH ON THE ACTION OF L. G. 11457 (DIALICOR) IN EXPERIMENTAL ANIMALS]. Minerva Cardioangiol. 1965 Mar;13:151-6. Italian. PubMed PMID: 14311176. 20: Del Giallo P, Valiensi M. [Controlled clinical study of a coronary active drug (etaphenone chlorhydrate) for parenteral administration]. Minerva Cardioangiol. 1972 Nov;20(11):642-57. Italian. PubMed PMID: 4566131.

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