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MedKoo Cat#: 597171 | Name: Folcysteine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Folcysteine is a cysteine derivative with potential antitumor agent, a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.

Chemical Structure

Folcysteine
Folcysteine
CAS#8064-47-9

Theoretical Analysis

MedKoo Cat#: 597171

Name: Folcysteine

CAS#: 8064-47-9

Chemical Formula: C25H28N8O9S

Exact Mass:

Molecular Weight: 616.61

Elemental Analysis: C, 48.70; H, 4.58; N, 18.17; O, 23.35; S, 5.20

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Related CAS #
59-30-3 (free) 8064-47-9
Synonym
Folcysteine; Ergostim; FOP;
IUPAC/Chemical Name
(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid compound with (R)-3-acetylthiazolidine-4-carboxylic acid (1:1)
InChi Key
VYRZTJJEGHJETR-OEFIRVHCSA-N
InChi Code
InChI=1S/C19H19N7O6.C6H9NO3S/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28;1-4(8)7-3-11-2-5(7)6(9)10/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30);5H,2-3H2,1H3,(H,9,10)/t12-;5-/m00/s1
SMILES Code
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CN=C3N=C(N)NC(C3=N2)=O)C=C1)=O.O=C([C@H]4N(C(C)=O)CSC4)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 616.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Weber HU, Fleming JF, Miquel J. Thiazolidine-4-carboxylic acid, a physiologic sulfhydryl antioxidant with potential value in geriatric medicine. Arch Gerontol Geriatr. 1982 Dec;1(4):299-310. Review. PubMed PMID: 6764606. 2: Boerescu J, Gheorghe N. [Biochemical changes in rat skin after prolonged and supralethal gamma-irradiation]. Physiologie. 1981 Jan-Mar;18(1):31-5. French. PubMed PMID: 6794049. 3: Moldoveanu E, Klein R, Bartoc R, Bruhis S, Oeriu I. Biosynthesis and operating mechanism of estrogens in ovariectomized animals under the effect of -SH groups. Mech Ageing Dev. 1975 Sep-Dec;4(5-6):423-9. PubMed PMID: 1228340. 4: Otel V, Costin G, Oeriu I. The use of folcysteine for the control of embryo mortality in pigs. II. Results of large-scale experiments. Zentralbl Veterinarmed A. 1972 Oct;19(9):766-8. PubMed PMID: 4629463. 5: Stefănescu GA, Severin V, Ionită E, Oeriu I. Rate of weight gain in chickens under the influence of folcysteine. Zentralbl Veterinarmed A. 1972 Oct;19(9):736-42. PubMed PMID: 4629460. 6: Bălăşescu M, Stefănescu GA, Oeriu I. Action exerted on the incubation indices of eggs by folcysteine administered to breeding poultry. Zentralbl Veterinarmed A. 1972 Jun;19(6):529-33. PubMed PMID: 4626303. 7: Stefanescu GA, Severin V, Balasescu M, Ionita E, Oeriu I, Oeriu S. [Influence of the biostimulator Folcysteine A on the weight gain and feather development in chicks]. Zentralbl Veterinarmed A. 1970 Feb;17(2):185-90. German. PubMed PMID: 4989037. 8: Dinu M, Serban S, Oeriu I, Cîmpeanu R, Vîlcu B, Dumitraşc N, Cîrstea E, Curelaru P, Oeriu S. [Oeriu's folcysteine "A" as a factor stimulating growth and development of pigs. II. Preliminary note]. Stud Cercet Fiziol. 1968;13(2):141-4. Romanian. PubMed PMID: 5691361. 9: Oeriu S, Winter D, Sauvard S, Cojocaru V, Winter J. [Biochemical studies in acute experimental hepatic insufficiency under the action of folcysteine]. Stud Cercet Fiziol. 1968;13(1):31-5. Romanian. PubMed PMID: 5668539. 10: Oeriu S, Herscovici H, Singer D, Gane P. [Protective effect of folcysteine against acute radiation sickness]. Arzneimittelforschung. 1967 Oct;17(10):1336-7. German. PubMed PMID: 5632891. 11: Oeriu S, Sauvard S, Maltezeanu G, Winter D, Stanescu C, Tigheciu M, Cojocaru V. [The effect of folcysteine on the prostate of castrated animals and on disorders of the equilibrium of 17-ketosteroids in chronic prostattis and sexual asthenia in man]. Dtsch Gesundheitsw. 1967 Apr 27;22(17):794-6. German. PubMed PMID: 5627819. 12: Oeriu S, Dinu M, Serban S, Oeriu I, Cimpeanu R, Vîlcu B, Dumitraşc N, Cirstea E, Curelaru P. [SH-groups as a factor stimulating the process of growth and development of the animal organism. Action of Oeriu's "A" folcysteine on the absolute growth rate of the animal organism (Landrace hybrid pigs x M. Alb). Preliminary note I]. Stud Cercet Fiziol. 1967;12(5):363-7. Romanian. PubMed PMID: 6082531. 13: Oeriu S, Tănase I, Benesch H, Crăcea M. Aminoacids from hydrolysates of Mycobacterium paratuberculosis (smegmatis) and Mycobacterium tuberculosis in relation to age and in the presence of cysteine and folcysteine. Arch Roum Pathol Exp Microbiol. 1965 Sep;24(3):641-50. PubMed PMID: 4961606. 14: Oeriu S. [Disorders of metabolism of sulfhydryl group substances and of free ammonia in the brain as a factor in the genesis of senile asthenia, amnesia and asthenic neuroses and the action of folcysteine on disturbed biochemical and physiological equilibrium]. Stud Cercet Fiziol. 1965;10(3):237-43. Romanian. PubMed PMID: 5892427. 15: Oeriu S, Costescu G, Teodorescu O, Soimu I, Damian O. Changes in thiol enzyme activity, as occurring in the aged body under the influence of folcysteine administration. Gerontologia. 1965;11(3):222-5. PubMed PMID: 5865225.