MedKoo Cat#: 565113 | Name: Acetylaminofluorene-dG

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Acetylaminofluorene-dG is a carcinogenic adduct which covalently binds DNA bases and promotes mutagenesis near the adduct site.

Chemical Structure

Acetylaminofluorene-dG
Acetylaminofluorene-dG
CAS#37819-60-6

Theoretical Analysis

MedKoo Cat#: 565113

Name: Acetylaminofluorene-dG

CAS#: 37819-60-6

Chemical Formula: C25H24N6O5

Exact Mass: 488.1808

Molecular Weight: 488.50

Elemental Analysis: C, 61.47; H, 4.95; N, 17.20; O, 16.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Acetylaminofluorene-dG; dG-8-AAF; 8-AAF-dG; 8 AAF-dG; 8-AAF dG
IUPAC/Chemical Name
N-(2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-8-yl)-N-(9H-fluoren-2-yl)acetamide
InChi Key
QHNMSPBQWLPAMP-XUVXKRRUSA-N
InChi Code
InChI=1S/C25H24N6O5/c1-12(33)30(15-6-7-17-14(9-15)8-13-4-2-3-5-16(13)17)25-27-21-22(28-24(26)29-23(21)35)31(25)20-10-18(34)19(11-32)36-20/h2-7,9,18-20,32,34H,8,10-11H2,1H3,(H3,26,28,29,35)/t18-,19+,20+/m0/s1
SMILES Code
CC(N(C1=NC2=C(N=C(N)NC2=O)N1[C@@H]3O[C@H](CO)[C@@H](O)C3)C4=CC(CC5=C6C=CC=C5)=C6C=C4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 488.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xu L, Cho BP. Conformational Insights into the Mechanism of Acetylaminofluorene-dG-Induced Frameshift Mutations in the NarI Mutational Hotspot. Chem Res Toxicol. 2016 Feb 15;29(2):213-26. doi: 10.1021/acs.chemrestox.5b00484. Epub 2016 Jan 15. PubMed PMID: 26733364. 2: Schorr S, Carell T. Mechanism of acetylaminofluorene-dG induced frameshifting by polymerase η. Chembiochem. 2010 Dec 10;11(18):2534-7. doi: 10.1002/cbic.201000579. PubMed PMID: 21064171. 3: Guo D, Xie Z, Shen H, Zhao B, Wang Z. Translesion synthesis of acetylaminofluorene-dG adducts by DNA polymerase zeta is stimulated by yeast Rev1 protein. Nucleic Acids Res. 2004 Feb 11;32(3):1122-30. Print 2004. PubMed PMID: 14960722; PubMed Central PMCID: PMC373411.