IUPAC/Chemical Name
N-acetyl-S-(4-(2-(2-(2-(hydroxyamino)-2-oxoethyl)heptanoyl)hexahydropyridazine-3-carboxamido)-5-methyl-3-oxoheptyl)-L-cysteine
InChi Key
FKOLSKSZEQBBHL-IKXKWNMQSA-N
InChi Code
InChI=1S/C27H47N5O8S/c1-5-7-8-10-19(15-23(35)31-40)26(37)32-21(11-9-13-28-32)25(36)30-24(17(3)6-2)22(34)12-14-41-16-20(27(38)39)29-18(4)33/h17,19-21,24,28,40H,5-16H2,1-4H3,(H,29,33)(H,30,36)(H,31,35)(H,38,39)/t17?,19?,20-,21?,24?/m0/s1
SMILES Code
O=C(O)[C@H](CSCCC(C(NC(C1CCCNN1C(C(CC(NO)=O)CCCCC)=O)=O)C(C)CC)=O)NC(C)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
601.76
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Tamaki K, Tanzawa K, Kurihara S, Oikawa T, Monma S, Shimada K, Sugimura Y. Synthesis and structure-activity relationships of gelatinase inhibitors derived from matlystatins. Chem Pharm Bull (Tokyo). 1995 Nov;43(11):1883-93. PubMed PMID: 8575029.
3: Ogita T, Sato A, Enokita R, Suzuki K, Ishii M, Negishi T, Okazaki T, Tamaki K, Tanzawa K. Matlystatins, new inhibitors of typeIV collagenases from Actinomadura atramentaria. I. Taxonomy, fermentation, isolation, and physico-chemical properties of matlystatin-group compounds. J Antibiot (Tokyo). 1992 Nov;45(11):1723-32. PubMed PMID: 1468979.
4: Tanzawa K, Ishii M, Ogita T, Shimada K. Matlystatins, new inhibitors of typeIV collagenases from Actinomadura atramentaria. II. Biological activities. J Antibiot (Tokyo). 1992 Nov;45(11):1733-7. PubMed PMID: 1361486.
