MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 407925 | Name: GCN2iB acetate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GCN2iB is a GCN2 inhibitor. GCN2iB may be useful for the treatment of cancer. The inhibition of GCN2 sensitizes cancer cells with low basal-level expression of asparagine synthetase (ASNS) to the antileukemic agent L-asparaginase (ASNase) in vitro and in vivo.

Chemical Structure

GCN2iB acetate
GCN2iB acetate
CAS#2183470-13-3 (acetate)

Theoretical Analysis

MedKoo Cat#: 407925

Name: GCN2iB acetate

CAS#: 2183470-13-3 (acetate)

Chemical Formula: C20H16ClF2N5O5S

Exact Mass: 0.0000

Molecular Weight: 511.88

Elemental Analysis: C, 46.93; H, 3.15; Cl, 6.93; F, 7.42; N, 13.68; O, 15.63; S, 6.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
2183470-12-2 (free base) 2183470-13-3 (acetate)
Synonym
GCN2iB; GCN2iB acetate.
IUPAC/Chemical Name
N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide acetic acid
InChi Key
QNHLMBSUYPVOLX-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H12ClF2N5O3S.C2H4O2/c1-29-17-15(6-11(19)9-23-17)30(27,28)26-14-5-4-13(20)12(16(14)21)3-2-10-7-24-18(22)25-8-10;1-2(3)4/h4-9,26H,1H3,(H2,22,24,25);1H3,(H,3,4)
SMILES Code
O=S(C1=CC(Cl)=CN=C1OC)(NC2=CC=C(F)C(C#CC3=CN=C(N)N=C3)=C2F)=O.CC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
General control nonderepressible 2 (GCN2) plays a major role in the cellular response to amino acid limitation. inhibition of GCN2 sensitizes cancer cells with low basal-level expression of asparagine synthetase (ASNS) to the antileukemic agent L-asparaginase (ASNase) in vitro and in vivo.

Preparing Stock Solutions

The following data is based on the product molecular weight 511.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response Akito Nakamura, Tadahiro Nambu, Shunsuke Ebara, Yuka Hasegawa, Kosei Toyoshima, Yasuko Tsuchiya, Daisuke Tomita, Jun Fujimoto, Osamu Kurasawa, Chisato Takahara, Ayumi Ando, Ryuichi Nishigaki, Yoshinori Satomi, Akito Hata, and Takahito Hara PNAS August 14, 2018. 115 (33) E7776-E7785; published ahead of print July 30, 2018. https://doi.org/10.1073/pnas.1805523115 Add to Cart ($10)

View History

JNJ-39933673

JNJ-39933673

Salinosporamide C

Salinosporamide C

IFNalpha-IFNAR-IN-1 HCl

IFNalpha-IFNAR-IN-1 HCl

IEM-525 HCl

IEM-525 HCl

Ifoxetine

Ifoxetine

(+)-Biotin-PEG10-OH

(+)-Biotin-PEG10-OH