Synonym
Droprenilamine HCl; Droprenilamine hydrochloride; MG8926; MG-8926; MG 8926; Valcor
IUPAC/Chemical Name
Benzenepropanamine, N-(2-cyclohexyl-1-methylethyl)-phenyl-, hydrochloride (8CI)
InChi Key
DHCUYKDNYXYZLM-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H33N.ClH/c1-20(19-21-11-4-2-5-12-21)25-18-10-16-23-15-8-9-17-24(23)22-13-6-3-7-14-22;/h3,6-9,13-15,17,20-21,25H,2,4-5,10-12,16,18-19H2,1H3;1H
SMILES Code
CC(NCCCC1=CC=CC=C1C2=CC=CC=C2)CC3CCCCC3.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Droprenilamine HCl is a biochemical.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
371.99
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Nakanishi H, Matsuoka I, Ono T, Yoshida H, Uchibori T, Kogi K. Effect of a prenylamine analog (MG8926) on spontaneous action potentials in isolated rabbit sinoatrial node. Fukushima J Med Sci. 1996 Dec;42(1-2):1-10. PubMed PMID: 9127964.
2: Baratta L, Mastrocola C, Lanciotti G, Petrosillo N, Tubani L, Iannetti A, Avella A. [Comparison of 2 groups of patients with ischemic cardiopathy treated with droprenylamine and prenylamine]. Minerva Cardioangiol. 1982 Jun;30(6):299-302. Italian. PubMed PMID: 7133418.
3: Rengo F, Trimarco B, Volpe M, Ricciadelli B, Morrone G, De Simone A, Condorelli M. [Clinical evaluation of a new antianginal drug: droprenylamine]. G Ital Cardiol. 1980;10(4):473-5. Italian. PubMed PMID: 7002693.
4: Baratta L, Mastrocola C, Petrosillo N, Guerrieri P, Leone G, Lanciotti G. [Clinical and electrocardiographic evaluation of the effectiveness of droprenylamine in patients with ischemic cardiopathy]. Minerva Cardioangiol. 1979 Nov;27(11):709-18. Italian. PubMed PMID: 545178.
