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MedKoo Cat#: 533054 | Name: GCN2 Inhibitor A-92
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GCN2 Inhibitor A-92 is a novel inhibitor of general control nonderepressible 2 kinase (GCN2 or EIF2AK4) stress response.

Chemical Structure

GCN2 Inhibitor A-92
GCN2 Inhibitor A-92
CAS#1448693-69-3

Theoretical Analysis

MedKoo Cat#: 533054

Name: GCN2 Inhibitor A-92

CAS#: 1448693-69-3

Chemical Formula: C19H18N10O

Exact Mass: 402.1665

Molecular Weight: 402.42

Elemental Analysis: C, 56.71; H, 4.51; N, 34.81; O, 3.98

Price and Availability

Size Price Availability Quantity
25mg USD 650.00 2 Weeks
50mg USD 1,150.00 2 Weeks
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Related CAS #
No Data
Synonym
GCN2 Inhibitor A-92; GCN2-IN-1; A-92; GCN2 Inhibitor 1; General Control Nonderepressible 2 Kinase Inhibitor 1
IUPAC/Chemical Name
1-(1H-Indazol-6-yl)-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-3-yl)-1H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine
InChi Key
BWNLUTKKCVJOHI-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18N10O/c1-2-14(9-15-12(1)10-21-24-15)29-16-11-20-19(23-18(16)25-27-29)22-17-3-6-28(26-17)13-4-7-30-8-5-13/h1-3,6,9-11,13H,4-5,7-8H2,(H,21,24)(H,20,22,23,26)
SMILES Code
C1(NC2=NN(C3CCOCC3)C=C2)=NC=C(N(C4=CC5=C(C=C4)C=NN5)N=N6)C6=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
GCN2-IN-1 (A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 60.0 149.10
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 402.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD

View History

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