MedKoo Cat#: 591504 | Name: Tampramine fumarate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed. Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.

Chemical Structure

Tampramine fumarate
Tampramine fumarate
CAS#83166-18-1 (fumarate)

Theoretical Analysis

MedKoo Cat#: 591504

Name: Tampramine fumarate

CAS#: 83166-18-1 (fumarate)

Chemical Formula: C27H28N4O4

Exact Mass: 472.2111

Molecular Weight: 472.55

Elemental Analysis: C, 68.63; H, 5.97; N, 11.86; O, 13.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Tampramine fumarate; AHR 9377; AHR-9377; AHR9377
IUPAC/Chemical Name
11H-Pyrido(2,3-b)(1,4)benzodiazepine-11-propanamine, N,N-dimethyl-6-phenyl-, (E)-2-butenedioate (1:1)
InChi Key
USQAILMOWHOBTK-WLHGVMLRSA-N
InChi Code
InChI=1S/C23H24N4.C4H4O4/c1-26(2)16-9-17-27-21-14-7-6-12-19(21)22(18-10-4-3-5-11-18)25-20-13-8-15-24-23(20)27;5-3(6)1-2-4(7)8/h3-8,10-15H,9,16-17H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
SMILES Code
CN(C)CCCN1C2=NC=CC=C2N=C(C3=CC=CC=C3)C4=CC=CC=C41.O=C(O)/C=C/C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 472.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: O'Donnell JM, Seiden LS. Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate. Psychopharmacology (Berl). 1985;87(3):283-5. PubMed PMID: 3936083. 2: Kinnier WJ, Tabor RD, Norrell LY. Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake. Biochem Pharmacol. 1984 Oct 1;33(19):3001-5. PubMed PMID: 6548381.