Clonidine hydrochloride | CAS#4205-91-8 | hypotensive agent

MedKoo Cat#: 558079 | Name: Clonidine hydrochloride

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clonidine hydrochloride is an alpha-agonist hypotensive agent.

Chemical Structure

Clonidine hydrochloride

CAS#4205-91-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 558079

Name: Clonidine hydrochloride

CAS#: 4205-91-8 (HCl)

Chemical Formula: C9H10Cl3N3

Exact Mass: 264.9900

Molecular Weight: 266.55

Elemental Analysis: C, 40.55; H, 3.78; Cl, 39.90; N, 15.76

Price and Availability

Size	Price	Availability	Quantity
1g	USD 285.00	2 Weeks
5g	USD 650.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

4205-90-7 (free base) 4205-91-8 (HCl)

Synonym

Clonidine HCl; ST-155; ST155; ST 155; NSC-756699; NSC756699; NSC 756699

IUPAC/Chemical Name

1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-, monohydrochloride (9CI)

InChi Key

ZNIFSRGNXRYGHF-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H

SMILES Code

ClC1=C(NC2=NCCN2)C(Cl)=CC=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.

In vitro activity:

HCEP cells were treated with various doses of clonidine for 1-28 h, resulting in abnormal morphology, decline of cell viability and G1 phase arrest in a time- and/or dose-dependent manner. Reference: Toxicol Sci. 2017 Mar 1;156(1):252-260. https://pubmed.ncbi.nlm.nih.gov/28115640/

In vivo activity:

Clonidine (0.05, 0.1 mg/kg, ip) inhibited synaptic plasticity in a dose-dependent manner, accompanying with the decreasing of aortic pressure and heart rate (HR) in anesthetized rats. Clonidine (1.25, 2.5 μg/kg, icv, 10 min before HFS) also dose-dependently inhibited synaptic plasticity, which had no remarkable effect on HR and aortic pressure. Reference: Cell Mol Neurobiol. 2013 Nov;33(8):1075-86. https://pubmed.ncbi.nlm.nih.gov/23975095/

	Solvent	mg/mL	mM
Solubility
	DMSO	19.2	72.14
	DMF	0.3	1.13
	Ethanol	27.5	103.17
	PBS (pH 7.2)	5.0	18.76
	Water	37.7	141.29

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 266.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Fan D, Fan TJ. Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway. Toxicol Sci. 2017 Mar 1;156(1):252-260. doi: 10.1093/toxsci/kfw249. PMID: 28115640. 2. Li CJ, Zhou M, Li HG, Lv Q, Xu XL, Guo LJ. Clonidine suppresses the induction of long-term potentiation by inhibiting HCN channels at the Schaffer collateral-CA1 synapse in anesthetized adult rats. Cell Mol Neurobiol. 2013 Nov;33(8):1075-86. doi: 10.1007/s10571-013-9974-z. Epub 2013 Aug 22. PMID: 23975095.

In vitro protocol:

In vivo protocol:

1. Li CJ, Zhou M, Li HG, Lv Q, Xu XL, Guo LJ. Clonidine suppresses the induction of long-term potentiation by inhibiting HCN channels at the Schaffer collateral-CA1 synapse in anesthetized adult rats. Cell Mol Neurobiol. 2013 Nov;33(8):1075-86. doi: 10.1007/s10571-013-9974-z. Epub 2013 Aug 22. PMID: 23975095.

1: Sulheim D, Fagermoen E, Winger A, Andersen AM, Godang K, Müller F, Rowe PC, Saul JP, Skovlund E, Øie MG, Wyller VB. Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-sectional and randomized clinical trial. JAMA Pediatr. 2014 Apr;168(4):351-60. doi: 10.1001/jamapediatrics.2013.4647. PubMed PMID: 24493300. 2: de Goede AL, Boedhram RR, Eckhardt M, Hanff LM, Koch BC, Vermaat CH, Vermes A. Development and validation of a paediatric oral formulation of clonidine hydrochloride. Int J Pharm. 2012 Aug 20;433(1-2):119-20. doi: 10.1016/j.ijpharm.2012.04.055. Epub 2012 May 9. PubMed PMID: 22580108. 3: Jellinge ME, Petersen RH. [Clonidine can reduce opioid medication during post-operative pain]. Ugeskr Laeger. 2015 Nov 30;177(49):V05150415. Review. Danish. PubMed PMID: 26651552. 4: Xu B, Wang Y, Zhu H. Mini-tablet combination for sustained release of clonidine hydrochloride and hydrochlorothiazide: Preparation and pharmacokinetics in beagle dogs. Pharmazie. 2016 Feb;71(2):76-83. PubMed PMID: 27004371. 5: Levinson ML, Johnson CE. Stability of an extemporaneously compounded clonidine hydrochloride oral liquid. Am J Hosp Pharm. 1992 Jan;49(1):122-5. PubMed PMID: 1570852. 6: Shimmura M, Kawamura N, Tateishi T, Shigeto H, Murai H, Kira J. [A case of paroxysmal sympathetic storm after acute disseminated encephalomyelitis and hypoxic encephalopathy responding to clonidine hydrochloride]. Rinsho Shinkeigaku. 2016;56(2):108-11. doi: 10.5692/clinicalneurol.cn-000793. Epub 2016 Jan 9. Japanese. PubMed PMID: 26754594. 7: Jain R, Segal S, Kollins SH, Khayrallah M. Clonidine extended-release tablets for pediatric patients with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2011 Feb;50(2):171-9. doi: 10.1016/j.jaac.2010.11.005. PubMed PMID: 21241954. 8: Khan LG, Razvi N, Anjum F, Siddiqui SA, Ghayas S. Effects of various excipients on tizanidine hydrochloride tablets prepared by direct compression. Pak J Pharm Sci. 2014 Sep;27(5):1249-54. PubMed PMID: 25176379. 9: Bekö SL, Thoms SD, Schmidt MU, Bolte M. Tizanidine and tizanidine hydrochloride: on the correct tautomeric form of tizanidine. Acta Crystallogr C. 2012 Jan;68(Pt 1):o28-32. doi: 10.1107/S0108270111052012. Epub 2011 Dec 9. PubMed PMID: 22223284. 10: Sumiya K, Baba Y, Inomata S, Toyooka H, Kohda Y. [Preparation and clinical evaluation of orally-disintegrating clonidine hydrochloride tablets for preanesthetic medication]. Yakugaku Zasshi. 2000 Jul;120(7):652-6. Japanese. PubMed PMID: 10920719. 11: Wulf H, Gleim M, Mignat C. The stability of mixtures of morphine hydrochloride, bupivacaine hydrochloride, and clonidine hydrochloride in portable pump reservoirs for the management of chronic pain syndromes. J Pain Symptom Manage. 1994 Jul;9(5):308-11. PubMed PMID: 7963782. 12: Datey KK, Bhagat SJ, Goyal BK, Mishra SJ, Kapadia NM, Rajlaxmi BN. Clonidine hydrochloride (catapres) in the management of hypertension. Indian J Chest Dis. 1975 Oct;17(4):158-65. PubMed PMID: 1218938. 13: Li F, McMahon C, Li F, Zulkoski J. LC-MS/MS sensitivity enhancement using 2D-SCX/RPLC and its application in the assessment of pharmacokinetics of clonidine in dried blood spots. Bioanalysis. 2011 Jul;3(14):1577-86. doi: 10.4155/bio.11.119. PubMed PMID: 21756091. 14: Kollins SH, Jain R, Brams M, Segal S, Findling RL, Wigal SB, Khayrallah M. Clonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with ADHD. Pediatrics. 2011 Jun;127(6):e1406-13. doi: 10.1542/peds.2010-1260. Epub 2011 May 9. PubMed PMID: 21555501; PubMed Central PMCID: PMC3387872. 15: Croxtall JD. Clonidine extended-release: in attention-deficit hyperactivity disorder. Paediatr Drugs. 2011 Oct 1;13(5):329-36. doi: 10.2165/11208100-000000000-00000. Review. PubMed PMID: 21888447. 16: Sumiya K, Homma M, Watanabe M, Baba Y, Inomata S, Kihara S, Toyooka H, Kohda Y. Sedation and plasma concentration of clonidine hydrochloride for pre-anesthetic medication in pediatric surgery. Biol Pharm Bull. 2003 Apr;26(4):421-3. PubMed PMID: 12673018. 17: Houston MC. Clonidine hydrochloride. South Med J. 1982 Jun;75(6):713-9. Review. PubMed PMID: 7046065. 18: Landis GA, Zimmet SM. Arterial thrombosis with combined clonidine hydrochloride and propranolol hydrochloride therapy. Arch Intern Med. 1980 Jan;140(1):135. PubMed PMID: 7352793. 19: Walters SM, Stonys DB. Determination of chlorthalidone and clonidine hydrochloride in tablets by HPLC. J Chromatogr Sci. 1983 Jan;21(1):43-5. PubMed PMID: 6833444. 20: Marinkovic M, Newfield RS. Self-limiting hematuria following growth hormone provocative testing with arginine hydrochloride. J Pediatr Endocrinol Metab. 2012;25(7-8):791-3. PubMed PMID: 23155712.

View History

Methylbenzethonium chloride

MedKoo CAT#: 592833

CAS#: 1320-44-1