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MedKoo Cat#: 413132 | Name: Clomegestone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clomegestone also known as 6-chloro-17α-hydroxy-16α-methylpregna-4,6-diene-3,20-dione, is a steroidal progestin of the 17α-hydroxyprogesterone group

Chemical Structure

Clomegestone
Clomegestone
CAS#5367-84-0 (free base)

Theoretical Analysis

MedKoo Cat#: 413132

Name: Clomegestone

CAS#: 5367-84-0 (free base)

Chemical Formula: C22H29ClO3

Exact Mass: 376.1805

Molecular Weight: 376.92

Elemental Analysis: C, 70.11; H, 7.76; Cl, 9.41; O, 12.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
424-89-5 (acetate) 5367-84-0 (free base)
Synonym
Clomegestone; Clomegestona; Clomegestonum; 6-chloro-17α-hydroxy-16α-methylpregna-4,6-diene-3,20-dione
IUPAC/Chemical Name
6-Chloro-17-hydroxy-16alpha-methylpregna-4,6-diene-3,20-dione
InChi Key
GQBSINXSPAZDSK-ROXMKHFISA-N
InChi Code
InChI=1S/C22H29ClO3/c1-12-9-17-15-11-19(23)18-10-14(25)5-7-20(18,3)16(15)6-8-21(17,4)22(12,26)13(2)24/h10-12,15-17,26H,5-9H2,1-4H3/t12-,15-,16+,17+,20-,21+,22+/m1/s1
SMILES Code
CC([C@@]1(O)[C@H](C)C[C@@]2([H])[C@]3([H])C=C(Cl)C4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 376.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schillinger E, Gerloff C, Gerhards E, Günzel P. Glucose tolerance and serum insulin in rats and insulin sensitivity of rat adipose cells following treatment with the progestogen clomegestone acetate. Acta Endocrinol (Copenh). 1974 Feb;75(2):305-13. doi: 10.1530/acta.0.0750305. PMID: 4406547. 2: Krauth MC, Schillinger E. Changes in insulin receptor concentration in rat fat cells following treatment with the gestagens clomegestone acetate and cyproterone acetate. Acta Endocrinol (Copenh). 1977 Nov;86(3):667-72. doi: 10.1530/acta.0.0860667. PMID: 579029.