MedKoo Cat#: 535238 | Name: Clomocycline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clomocycline is a bioactive chemical.

Chemical Structure

Clomocycline
Clomocycline
CAS#1181-54-0

Theoretical Analysis

MedKoo Cat#: 535238

Name: Clomocycline

CAS#: 1181-54-0

Chemical Formula: C23H27ClN2O9

Exact Mass: 510.1405

Molecular Weight: 510.92

Elemental Analysis: C, 54.07; H, 5.33; Cl, 6.94; N, 5.48; O, 28.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Clomocycline
IUPAC/Chemical Name
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,2,3,4,4a,5,5a,6,11,12a-decahydro-1,11-dioxo-N-(hydroxymethyl)-6-methyl-3,6,10,12,12a-pentahydroxy-
InChi Key
QCUVOKKMOWFBPX-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H27ClN2O9/c1-22(34)8-6-9-16(26(2)3)18(30)14(21(33)25-7-27)20(32)23(9,35)19(31)12(8)17(29)13-11(28)5-4-10(24)15(13)22/h4-5,8-9,14,16,18,27-28,30-31,34-35H,6-7H2,1-3H3,(H,25,33)
SMILES Code
O=C(C(C(O)C(N(C)C)C1CC2C(O)(C)C3=C(C(C2=C(O)C14O)=O)C(O)=CC=C3Cl)C4=O)NCO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 510.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ward JM, Corbett MF, Hanna MJ. A double-blind trial of clomocycline in the treatment of persistent palmoplantar pustulosis. Br J Dermatol. 1976 Sep;95(3):317-22. doi: 10.1111/j.1365-2133.1976.tb07020.x. PMID: 788767. 2: Andrew GS, Edwards JC, Oller LZ. Clinical trial of clomocycline (Megaclor) in gonococcal and non-gonococcal urethritis. Br J Vener Dis. 1969 Jun;45(2):154-6. doi: 10.1136/sti.45.2.154. PMID: 4892122; PMCID: PMC1048457. 3: Ganpule M. Clomocycline and oxytetracycline in acne vulgaris. Practitioner. 1968 Sep;201(203):479-82. PMID: 4234717. 4: Marshall BU. A clinical trial of clomocycline in general practice. Practitioner. 1966 Sep;197(179):362-4. PMID: 5330926. 5: Kelly PM. Clinical evaluation of clomocycline ('Megaclor') in urological surgery. Br J Clin Pract. 1966 Nov;20(11):576-7. PMID: 5342075. 6: Wells BW. Clinical evaluation of clomocycline ('Megaclor') in general surgical practice. Br J Clin Pract. 1966 Nov;20(11):573-5. PMID: 5342074. 7: Appleyard WJ, Rake MO. The use of clomocycline ('Megaclor') in acute respiratory infections. Br J Clin Pract. 1968 Sep;22(9):397-8. PMID: 5672548. 8: Potts RC, MacConnachie A, Brown RA, Gibbs JH, Robertson AJ, Hassan HA, Beck JS. Some tetracycline drugs suppress mitogen-stimulated lymphocyte growth but others do not. Br J Clin Pharmacol. 1983 Aug;16(2):127-32. doi: 10.1111/j.1365-2125.1983.tb04975.x. PMID: 6615686; PMCID: PMC1427975.