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MedKoo Cat#: 591328 | Name: Pseudoephedrine sulfate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pseudoephedrine is a sympathomimetic amine that primarily acts as an α- and β-adrenergic receptor agonist. It functions by stimulating the release of norepinephrine from presynaptic nerve terminals, leading to vasoconstriction. This reduces nasal congestion by shrinking swollen mucous membranes and decreasing fluid leakage into nasal passages. Pseudoephedrine is used to study α- and β-adrenergic receptor activation, particularly its role in vasoconstriction and bronchodilation.Pseudoephedrine helps in understanding the norepinephrine release mechanism and its impact on cardiovascular and respiratory physiology.

Chemical Structure

Pseudoephedrine sulfate
Pseudoephedrine sulfate
CAS#7460-12-0 (sulfate)

Theoretical Analysis

MedKoo Cat#: 591328

Name: Pseudoephedrine sulfate

CAS#: 7460-12-0 (sulfate)

Chemical Formula: C20H32N2O6S

Exact Mass: 428.1981

Molecular Weight: 428.54

Elemental Analysis: C, 56.05; H, 7.53; N, 6.54; O, 22.40; S, 7.48

Price and Availability

Size Price Availability Quantity
100mg USD 950.00 2 Weeks
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Related CAS #
7460-12-0 (sulfate) 90-82-4 (free base) 345-78-8 (HCl)
Synonym
Pseudoephedrine sulfate; Afrin Tablets; Afrinol; Sch 4855
IUPAC/Chemical Name
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alphaS)-, sulfate (2:1)
InChi Key
CAVQBDOACNULDN-NRCOEFLKSA-N
InChi Code
InChI=1S/2C10H15NO.H2O4S/c2*1-8(11-2)10(12)9-6-4-3-5-7-9;1-5(2,3)4/h2*3-8,10-12H,1-2H3;(H2,1,2,3,4)/t2*8-,10+;/m00./s1
SMILES Code
C[NH2+][C@@H](C)[C@@H](O)C1=CC=CC=C1.C[NH2+][C@@H](C)[C@@H](O)C2=CC=CC=C2.O=S([O-])([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 428.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gelotte CK. An open-label, randomized, four-treatment crossover study evaluating the effects of salt form, acetaminophen, and food on the pharmacokinetics of phenylephrine. Regul Toxicol Pharmacol. 2018 Jun;95:333-338. doi: 10.1016/j.yrtph.2018.04.008. Epub 2018 Apr 7. PubMed PMID: 29635061. 2: Huo HL, Li HC, Wei P, Song S, Luo JB. [Changes in plasma pharmacokinetics and urinary excretion characteristics before and after combined administration of Ephedrae Herba-Gypsum Fibrosum]. Zhongguo Zhong Yao Za Zhi. 2015 Mar;40(5):963-70. Chinese. PubMed PMID: 26087564. 3: Zhang YL, Li YP. [Simultaneous determination of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid with HPLC]. Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3291-4. Chinese. PubMed PMID: 24422394. 4: Pilla R, Held HE, Landon CS, Dean JB. High doses of pseudoephedrine hydrochloride accelerate onset of CNS oxygen toxicity seizures in unanesthetized rats. Neuroscience. 2013 Aug 29;246:391-6. doi: 10.1016/j.neuroscience.2013.04.035. Epub 2013 Apr 24. PubMed PMID: 23624060. 5: Iwata YT, Mikuma T, Kuwayama K, Tsujikawa K, Miyaguchi H, Kanamori T, Inoue H. Applicability of chemically modified capillaries in chiral capillary electrophoresis for methamphetamine profiling. Forensic Sci Int. 2013 Mar 10;226(1-3):235-9. doi: 10.1016/j.forsciint.2013.01.033. Epub 2013 Feb 16. PubMed PMID: 23422168. 6: Fashner J, Ericson K, Werner S. Treatment of the common cold in children and adults. Am Fam Physician. 2012 Jul 15;86(2):153-9. Review. PubMed PMID: 22962927. 7: Shaw BJ, Semin DJ, Rider ME, Beebe MR. Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis. J Pharm Biomed Anal. 2012 Apr 7;63:151-9. doi: 10.1016/j.jpba.2012.01.037. Epub 2012 Feb 7. PubMed PMID: 22349883. 8: Krizevski R, Bar E, Shalit O, Sitrit Y, Ben-Shabat S, Lewinsohn E. Composition and stereochemistry of ephedrine alkaloids accumulation in Ephedra sinica Stapf. Phytochemistry. 2010 Jun;71(8-9):895-903. doi: 10.1016/j.phytochem.2010.03.019. Epub 2010 Apr 24. PubMed PMID: 20417943. 9: Onur F, Yücesoy C, Dermiş S, Kartal M, Kökdil G. Simultaneous determination of pseudoephedrine sulfate, dexbrompheniramine maleate and loratadine in pharmaceutical preparations using derivative spectrophotometry and ratio spectra derivative spectrophotometry. Talanta. 2000 Feb 7;51(2):269-79. PubMed PMID: 18967858. 10: Culzoni MJ, Goicoechea HC. Determination of loratadine and pseudoephedrine sulfate in pharmaceuticals based on non-linear second-order spectrophotometric data generated by a pH-gradient flow injection technique and artificial neural networks. Anal Bioanal Chem. 2007 Dec;389(7-8):2217-25. Epub 2007 Oct 23. PubMed PMID: 17955218. 11: Harris NR, Specian RD, Carter PR, Morgan GA. Contrasting effects of pseudoephedrine and papaverine in dextran sodium sulfate-induced colitis. Inflamm Bowel Dis. 2008 Mar;14(3):318-23. PubMed PMID: 17941078. 12: Larrain A, Hudson M, Dominitz JA, Pope CE 2nd. Treatment of severe snoring with a combination of pseudoephedrine sulfate and domperidone. J Clin Sleep Med. 2006 Jan 15;2(1):21-5. PubMed PMID: 17557432. 13: Zhang PH, Zhang L, Lu Y, Shi GY. [Purification and characterization of carbonyl enantioselective reductase from Morganella morganii J-8]. Sheng Wu Gong Cheng Xue Bao. 2007 Mar;23(2):268-72. Chinese. PubMed PMID: 17460900. 14: Wang C, Fan G, Lin M, Chen Y, Zhao W, Wu Y. Development and validation of a liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of D-amphetamine and diphenhydramine in beagle dog plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1;854(1-2):48-56. Epub 2007 Apr 5. PubMed PMID: 17452029. 15: Rizvi SA, Zheng J, Apkarian RP, Dublin SN, Shamsi SA. Polymeric sulfated amino acid surfactants: a class of versatile chiral selectors for micellar electrokinetic chromatography (MEKC) and MEKC-MS. Anal Chem. 2007 Feb 1;79(3):879-98. PubMed PMID: 17263313; PubMed Central PMCID: PMC2569972. 16: Knops LA, Northrop DM, Person EC. Capillary electrophoretic analysis of phosphorus species in clandestine methamphetamine laboratory samples. J Forensic Sci. 2006 Jan;51(1):82-6. PubMed PMID: 16423227. 17: Keast RS, Breslin PA. Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification. Pharm Res. 2005 Nov;22(11):1970-7. Epub 2005 Aug 26. PubMed PMID: 16132352. 18: Abu-Lathou A, Hamdan II, Tahraoui A. A new HPLC approach for the determination of hydrophilic and hydrophobic components: the case of pseudoephedrine sulfate and loratadine in tablets. Drug Dev Ind Pharm. 2005 Jul;31(6):577-88. PubMed PMID: 16109631. 19: Sun J, Wang G, Wang W, Zhao S, Gu Y, Zhang J, Huang M, Shao F, Li H, Zhang Q, Xie H. Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies. J Pharm Biomed Anal. 2005 Sep 1;39(1-2):217-24. PubMed PMID: 15953705. 20: Sznitowska M, Cal K, Kupiec K. Development of modified-release dosage forms containing loratadine and pseudoephedrine sulfate. Acta Pol Pharm. 2004 Dec;61 Suppl:72-4. PubMed PMID: 15909946.

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