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MedKoo Cat#: 596416 | Name: Pseudoephedrine free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pseudoephedrine is a sympathomimetic amine that primarily acts as an α- and β-adrenergic receptor agonist. It functions by stimulating the release of norepinephrine from presynaptic nerve terminals, leading to vasoconstriction. This reduces nasal congestion by shrinking swollen mucous membranes and decreasing fluid leakage into nasal passages. Pseudoephedrine is used to study α- and β-adrenergic receptor activation, particularly its role in vasoconstriction and bronchodilation.Pseudoephedrine helps in understanding the norepinephrine release mechanism and its impact on cardiovascular and respiratory physiology.

Chemical Structure

Pseudoephedrine free base
Pseudoephedrine free base
CAS#90-82-4 (free base)

Theoretical Analysis

MedKoo Cat#: 596416

Name: Pseudoephedrine free base

CAS#: 90-82-4 (free base)

Chemical Formula: C10H15NO

Exact Mass: 165.1154

Molecular Weight: 165.23

Elemental Analysis: C, 72.69; H, 9.15; N, 8.48; O, 9.68

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
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Related CAS #
7460-12-0 (sulfate) 90-82-4 (free base) 345-78-8 (HCl)
Synonym
Pseudoephedrine; Isoephedrine; Pseudoephedrinum; Pseudoefedrina; EINECS 202-018-6; HSDB 3177; Besan;
IUPAC/Chemical Name
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
InChi Key
KWGRBVOPPLSCSI-WCBMZHEXSA-N
InChi Code
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
SMILES Code
O[C@H]([C@@H](NC)C)C1=CC=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 165.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mullen JM, Crawford AT. Amphetamine Related Psychiatric Disorders. 2018 Jan 23. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK482368/ PubMed PMID: 29493990. 2: Suchecka D, Kucharska-Mazur J, Groszewska K, Mak M, Samochowiec J, Samochowiec A. [Analysis of the phenomenon of over-the-counter drug abuse and not controlled herbs trade by polish adolescents: Part I]. Med Pr. 2017 May 16;68(3):413-422. doi: 10.13075/mp.5893.00245. Epub 2017 Mar 28. Review. Polish. PubMed PMID: 28512368. 3: Hyuga S. The Pharmacological Actions of Ephedrine Alkaloids-free Ephreda Herb Extract and Preparation for Clinical Application. Yakugaku Zasshi. 2017;137(2):179-186. doi: 10.1248/yakushi.16-00233-4. Review. Japanese. PubMed PMID: 28154329. 4: Hale GM, Valdes J, Brenner M. The Treatment of Primary Orthostatic Hypotension. Ann Pharmacother. 2017 May;51(5):417-428. doi: 10.1177/1060028016689264. Epub 2017 Jan 16. Review. PubMed PMID: 28092986. 5: Deckx L, De Sutter AI, Guo L, Mir NA, van Driel ML. Nasal decongestants in monotherapy for the common cold. Cochrane Database Syst Rev. 2016 Oct 17;10:CD009612. Review. PubMed PMID: 27748955. 6: Abdel-Hamid IA, Elsaied MA, Mostafa T. The drug treatment of delayed ejaculation. Transl Androl Urol. 2016 Aug;5(4):576-91. doi: 10.21037/tau.2016.05.05. Review. PubMed PMID: 27652229; PubMed Central PMCID: PMC5001980. 7: Sawatsubashi M. [Clinical Management of Japanese Cedar Pollinosis]. Fukuoka Igaku Zasshi. 2016 Jan;107(1):1-7. Review. Japanese. PubMed PMID: 27333653. 8: Stanciu CN, Penders TM, Rouse EM. Recreational use of dextromethorphan, "Robotripping"-A brief review. Am J Addict. 2016 Aug;25(5):374-7. doi: 10.1111/ajad.12389. Epub 2016 Jun 11. Review. PubMed PMID: 27288091. 9: Trimeloni L, Spencer J. Diagnosis and Management of Breast Milk Oversupply. J Am Board Fam Med. 2016 Jan-Feb;29(1):139-42. doi: 10.3122/jabfm.2016.01.150164. Review. PubMed PMID: 26769886. 10: Van Berkel MA, Fuller LA, Alexandrov AW, Jones GM. Methylene blue, midodrine, and pseudoephedrine: a review of alternative agents for refractory hypotension in the intensive care unit. Crit Care Nurs Q. 2015 Oct-Dec;38(4):345-58. doi: 10.1097/CNQ.0000000000000086. Review. PubMed PMID: 26335214. 11: Sikk K, Taba P. Methcathinone "Kitchen Chemistry" and Permanent Neurological Damage. Int Rev Neurobiol. 2015;120:257-71. doi: 10.1016/bs.irn.2015.02.002. Epub 2015 Mar 12. Review. PubMed PMID: 26070761. 12: Achuthan S, Medhi B. A systematic review of the pharmacological approaches against snoring: can we count on the chickens that have hatched? Sleep Breath. 2015 Sep;19(3):1035-42. doi: 10.1007/s11325-015-1123-0. Epub 2015 Feb 14. Review. PubMed PMID: 25680547. 13: Zhanel GG, Love R, Adam H, Golden A, Zelenitsky S, Schweizer F, Gorityala B, Lagacé-Wiens PR, Rubinstein E, Walkty A, Gin AS, Gilmour M, Hoban DJ, Lynch JP 3rd, Karlowsky JA. Tedizolid: a novel oxazolidinone with potent activity against multidrug-resistant gram-positive pathogens. Drugs. 2015 Feb;75(3):253-70. doi: 10.1007/s40265-015-0352-7. Review. PubMed PMID: 25673021. 14: Wright T. Middle-ear pain and trauma during air travel. BMJ Clin Evid. 2015 Jan 19;2015. pii: 0501. Review. PubMed PMID: 25599243; PubMed Central PMCID: PMC4298289. 15: Laccourreye O, Werner A, Giroud JP, Couloigner V, Bonfils P, Bondon-Guitton E. Benefits, limits and danger of ephedrine and pseudoephedrine as nasal decongestants. Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Feb;132(1):31-4. doi: 10.1016/j.anorl.2014.11.001. Epub 2014 Dec 19. Review. PubMed PMID: 25532441. 16: Basova NE, Kormilitsin BN, Perchenok AY, Rozengatt EV, Saakov VS, Suvorov AA. [Ligands of cholinesterases of ephedrine and pseudoephedrine structure]. Zh Evol Biokhim Fiziol. 2013 Nov-Dec;49(6):385-93. Review. Russian. PubMed PMID: 25490843. 17: Senchina DS, Hallam JE, Kohut ML, Nguyen NA, Perera MA. Alkaloids and athlete immune function: caffeine, theophylline, gingerol, ephedrine, and their congeners. Exerc Immunol Rev. 2014;20:68-93. Review. PubMed PMID: 24974722. 18: Sherid M, Samo S, Husein H, Sulaiman S, Vainder JA. Pseudoephedrine-induced ischemic colitis: case report and literature review. J Dig Dis. 2014 May;15(5):276-80. doi: 10.1111/1751-2980.12133. Review. PubMed PMID: 24612436. 19: Skeldon SC, Goldenberg SL. Urological complications of illicit drug use. Nat Rev Urol. 2014 Mar;11(3):169-77. doi: 10.1038/nrurol.2014.22. Epub 2014 Feb 18. Review. PubMed PMID: 24535583. 20: Habrat B, Baran-Furga H, Sienkiewicz-Jarosz H, Sein Anand J, Poniatowska R. [Encephalopathy caused by intravenous potassium permanganate used for illegal production of methcathinone (ephedrone) from medicines containing pseudoephedrine]. Przegl Lek. 2013;70(8):613-6. Review. Polish. PubMed PMID: 24466704.

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