Pseudoephedrine HCl | CAS#345-78-8 | Adrenergic Agonist

MedKoo Cat#: 318594 | Name: Pseudoephedrine HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pseudoephedrine is a sympathomimetic amine that primarily acts as an α- and β-adrenergic receptor agonist. It functions by stimulating the release of norepinephrine from presynaptic nerve terminals, leading to vasoconstriction. This reduces nasal congestion by shrinking swollen mucous membranes and decreasing fluid leakage into nasal passages. Pseudoephedrine is used to study α- and β-adrenergic receptor activation, particularly its role in vasoconstriction and bronchodilation.Pseudoephedrine helps in understanding the norepinephrine release mechanism and its impact on cardiovascular and respiratory physiology.

Chemical Structure

Pseudoephedrine HCl

CAS#345-78-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 318594

Name: Pseudoephedrine HCl

CAS#: 345-78-8 (HCl)

Chemical Formula: C10H16ClNO

Exact Mass: 0.0000

Molecular Weight: 201.69

Elemental Analysis: C, 59.55; H, 8.00; Cl, 17.58; N, 6.94; O, 7.93

Price and Availability

Size	Price	Availability	Quantity
25g	USD 550.00	2 Weeks

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Related CAS #

90-82-4 (free base) 345-78-8 (HCl) 7460-12-0 (sulfate)

Synonym

Pseudoephedrine Hydrochloride; Pseudoephedrine Hcl; Sudomyl; Tussaphed; Novafed; udafed.

IUPAC/Chemical Name

(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride

InChi Key

BALXUFOVQVENIU-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H

SMILES Code

CC(C(C1=CC=CC=C1)O)NC.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 201.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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A novel spectrofluorimetric method for the assay of pseudoephedrine hydrochloride in pharmaceutical formulations via derivatization with 4-chloro-7-nitrobenzofurazan. Luminescence. 2011 Nov-Dec;26(6):510-7. doi: 10.1002/bio.1261. Epub 2010 Nov 8. PubMed PMID: 22162453. 5: Yu LP, Wang XK, Luo JB. [Determination of ephedrine hydrochloride, pseudoephedrine hydrochloride and methylephedrine hydrochloride in maxingshigan decoction by CE]. Zhong Yao Cai. 2011 Apr;34(4):620-3. Chinese. PubMed PMID: 21809550. 6: Zeeshan F, Bukhari NI. Development and evaluation of a novel modified-release pellet-based tablet system for the delivery of loratadine and pseudoephedrine hydrochloride as model drugs. AAPS PharmSciTech. 2010 Jun;11(2):910-6. doi: 10.1208/s12249-010-9456-2. Epub 2010 May 22. PubMed PMID: 20496016; PubMed Central PMCID: PMC2902326. 7: Clinical Research Coordination Group of Guaifenesin Compound Pseudoephedrine Hydrochloride Oral Solution, Lu Q. [A prospective multicenter randomized controlled clinical study on the efficacy and safety of Guaifenesin compound pseudoephedrine hydrochloride oral solution]. Zhonghua Er Ke Za Zhi. 2010 Mar;48(3):204-7. Chinese. PubMed PMID: 20426957. 8: Kikano G. Safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for adjunctive symptom relief of acute respiratory infections. Postgrad Med. 2009 May;121(3):173-5. doi: 10.3810/pgm.2009.05.2018. PubMed PMID: 19491556. 9: Yang ZY, Lu Y, Tang X. Pseudoephedrine hydrochloride sustained-release pellets prepared by a combination of hot-melt subcoating and polymer coating. Drug Dev Ind Pharm. 2008 Dec;34(12):1323-30. doi: 10.1080/03639040802084938 . PubMed PMID: 18785047. 10: LaForce C, Gentile DA, Skoner DP. A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respiratory infections. Postgrad Med. 2008 Jul;120(2):53-9. doi: 10.3810/pgm.2008.07.1791. PubMed PMID: 18654069. 11: Chitlange SS, Sakarkar DM, Wankhede SB, Wadodkar SG. High performance thin layer chromatographic method for simultaneous estimation of Ibuprofen and pseudoephedrine hydrochloride. Indian J Pharm Sci. 2008 May-Jun;70(3):398-400. doi: 10.4103/0250-474X.43018. PubMed PMID: 20046759; PubMed Central PMCID: PMC2792507. 12: Zayed SI, Issa YM, Hussein A. Construction and performance characterization of ion-selective electrodes for potentiometric determination of pseudoephedrine hydrochloride applying batch and flow injection analysis techniques. Ann Chim. 2006 Jul-Aug;96(7-8):421-33. PubMed PMID: 16948431. 13: Likar MD, Mansour HL, Harwood JW. Development and validation of a dissolution test for a once-a-day combination tablet of immediate-release cetirizine dihydrochloride and extended-release pseudoephedrine hydrochloride. J Pharm Biomed Anal. 2005 Sep 15;39(3-4):543-51. PubMed PMID: 15975755. 14: Gu X, Li H, Macnair KR, Simons FE, Simons KJ. Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography. J Pharm Biomed Anal. 2005 Apr 1;37(4):663-7. Epub 2004 Dec 25. PubMed PMID: 15797786. 15: Safak MA, Kiliç R, Haberal I, Göçmen H, Ozeri C. A comparative study of azithromycin and pseudoephedrine hydrochloride for otitis media with effusion in children. Acta Otolaryngol. 2001 Dec;121(8):925-9. PubMed PMID: 11813896. 16: Ekpe A, Tong JH, Rodriguez L. High-performance liquid chromatographic method development and validation for the simultaneous quantitation of naproxen sodium and pseudoephedrine hydrochloride impurities. J Chromatogr Sci. 2001 Mar;39(3):81-6. PubMed PMID: 11277256. 17: Altuntas TG, Zanooz SS, Nebioglu D. Quantitative determination of acrivastine and pseudoephedrine hydrochloride in pharmaceutical formulation by high performance liquid chromatography and derivative spectrophotometry. J Pharm Biomed Anal. 1998 May;17(1):103-9. PubMed PMID: 9608432. 18: Hindioğlu U, Sahin S. Nonpigmenting solitary fixed drug eruption caused by pseudoephedrine hydrochloride. J Am Acad Dermatol. 1998 Mar;38(3):499-500. PubMed PMID: 9520039. 19: Dash AK. Determination of pseudoephedrine hydrochloride in dosage forms by liquid chromatography. J Pharm Biomed Anal. 1994 Dec;12(12):1601-6. PubMed PMID: 7696386. 20: Akhtar MJ, Khan S, Hafiz M. High-performance liquid chromatographic assay for the determination of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride. J Pharm Biomed Anal. 1994 Mar;12(3):379-82. PubMed PMID: 8031938.